Trim9 Tripartite motif containing 9 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Trim9provided by FlyBase
Official Full Name: Tripartite motif containing 9provided by FlyBase
Primary source: FLYBASE:FBgn0051721
Locus tag: Dmel_CG31721
See related: AllianceGenome:FB:FBgn0051721
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: asap; Asap; CG13145; cg31721; CG31721; CG6256; Dmel\CG31721; dTrim9; TRIM9
Summary: Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in several processes, including axonogenesis; negative regulation of glycolytic process; and netrin-activated signaling pathway. Located in axonal growth cone. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; head epidermis primordium; larval multidendritic class IV neuron; and sensory nervous system primordium. Orthologous to human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31F5-32A2; 2-43 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10544883..10628054)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10544883..10628054)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

topographic separation of the presynaptic terminals of adjacent nociceptive neurons requires different levels of Trim9, an evolutionarily conserved signaling molecule
Title: Trim9 regulates activity-dependent fine-scale topography in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycolytic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in netrin-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in netrin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in netrin-activated signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in peripheral nervous system neuron axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peripheral nervous system neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axonal growth cone	IGI Inferred from Genetic Interaction more info	PubMed
located_in axonal growth cone	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tripartite motif containing 9

Names: CG31721-PA; CG31721-PB; Trim9-PA; Trim9-PB; anomalies in sensory axon patterning

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10544883..10628054

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201857.2 → NP_001188786.1 tripartite motif containing 9, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188786.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9MRI4, Q86P21, Q9VKT3

Conserved Domains (5) summary

cd00063
Location:472 → 564

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd12889
Location:561 → 735

SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

pfam00643
Location:250 → 291

zf-B_box; B-box zinc finger

cd16576
Location:2 → 37

RING-HC_TRIM9_like_C-I; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM9, TRIM36, TRIM46, TRIM67, and similar proteins

cl25407
Location:298 → 420

ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
NM_164935.3 → NP_723600.2 tripartite motif containing 9, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723600.2

Status: REVIEWED

UniProtKB/Swiss-Prot

M9MRI4

Conserved Domains (4) summary

cd00063
Location:479 → 553

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00643
Location:250 → 291

zf-B_box; B-box zinc finger

cd12889
Location:550 → 724

SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

cl23765
Location:298 → 420

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits