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CG18302 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34452, updated on 9-Dec-2024

Summary

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Official Symbol
CG18302provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032266
Locus tag
Dmel_CG18302
See related
AllianceGenome:FB:FBgn0032266
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG18302
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid metabolic process. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG18302 in Genome Data Viewer
Location:
31F5-31F5; 2-43 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10534322..10536587)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10534322..10536587)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Lipase 4 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44618 Neighboring gene Tripartite motif containing 9 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatiotemporal dynamics and genome-wide association genome-wide association analysis of desiccation tolerance in Drosophila melanogaster. Rajpurohit S, et al. Mol Ecol, 2018 Sep. PMID 30051644, Free PMC Article
  2. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
  3. Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling. Wang T, et al. Proc Natl Acad Sci U S A, 2021 Mar 23. PMID 33723074, Free PMC Article
  4. Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model. Voutyraki C, et al. Proc Natl Acad Sci U S A, 2023 Aug 15. PMID 37549261, Free PMC Article
  5. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG18302-PA
NP_609420.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10534322..10536587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135576.3 → NP_609420.1  uncharacterized protein Dmel_CG18302 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609420.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQK7, Q9VKT7
    Related
    FBpp0079684
    Conserved Domains (3) summary
    PLN02872
    Location:13 → 399
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:43 → 97
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:79 → 208
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKT7 Q9VKT7

Gene LinkOut

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