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Lip4 Lipase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34450, updated on 9-Dec-2024

Summary

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Official Symbol
Lip4provided by FlyBase
Official Full Name
Lipase 4provided by FlyBase
Primary source
FLYBASE:FBgn0032264
Locus tag
Dmel_CG6113
See related
AllianceGenome:FB:FBgn0032264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6113; dlip4; dLip4; Dmel\CG6113; lip4
Summary
Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in lipid droplet. Is expressed in adult head; amnioserosa; and yolk nucleus. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Lip4 in Genome Data Viewer
Location:
31F5-31F5; 2-43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10527572..10531778)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10527572..10531778)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Fatty acid transport protein 1 Neighboring gene Leucine-rich repeat 47 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila transcription factor NF-Y suppresses transcription of the lipase 4 gene, a key gene for lipid storage. Yoshioka Y, et al. Exp Cell Res, 2022 Nov 1. PMID 36028059
  2. Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila. Kohyama-Koganeya A, et al. PLoS One, 2017. PMID 28045997, Free PMC Article
  3. Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction. Katzenberger RJ, et al. Elife, 2015 Mar 5. PMID 25742603, Free PMC Article
  4. dFOXO regulates transcription of a Drosophila acid lipase. Vihervaara T, et al. J Mol Biol, 2008 Mar 7. PMID 18234213
  5. JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Karpac J, et al. Aging Cell, 2009 Jun. PMID 19627268, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity HDA PubMed 
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lipase 4
Names
CG6113-PA
CG6113-PB
CG6113-PC
Lip4-PA
Lip4-PB
Lip4-PC
lipase4
NP_001188785.1
NP_001260356.1
NP_609418.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10527572..10531778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273427.1 → NP_001260356.1  lipase 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCU5
    Conserved Domains (3) summary
    PLN02872
    Location:88 → 446
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:88 → 139
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:121 → 253
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_001201856.2 → NP_001188785.1  lipase 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRM3
    Conserved Domains (3) summary
    PLN02872
    Location:74 → 430
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:74 → 125
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:107 → 239
    Abhydrolase_5; Alpha/beta hydrolase family

  3. NM_135574.4 → NP_609418.1  lipase 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609418.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKT9
    Related
    FBpp0079682
    Conserved Domains (3) summary
    PLN02872
    Location:74 → 432
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:74 → 125
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:107 → 239
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MRM3 M9MRM3
M9PCU5 M9PCU5
Q9VKT9 Q9VKT9

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