KdelR KDEL receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: KdelRprovided by FlyBase
Official Full Name: KDEL receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0267330
Locus tag: Dmel_CG5183
See related: AllianceGenome:FB:FBgn0267330
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:CK00230; CG5183; CK00230; dKDELR; Dmel\CG5183; dmErd2; Erd2; ERD2; Kdel; l(2)31Em; l(2)k00311
Summary: Predicted to enable KDEL sequence binding activity. Involved in protein retention in ER lumen. Predicted to be located in membrane. Predicted to be active in cis-Golgi network and endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gland; gut section; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 21. Orthologous to several human genes including KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10426887..10428632)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10426887..10428632)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A requirement for KdelR in maintaining the ER pool.
Title: Drosophila KDEL receptor function in the embryonic salivary gland and epidermis.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ER retention sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables ER retention sequence binding	IEA Inferred from Electronic Annotation more info
enables KDEL sequence binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in protein retention in ER lumen	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein retention in ER lumen	IEA Inferred from Electronic Annotation more info
involved_in protein retention in ER lumen	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

Names: CG5183-PA; CG5183-PB; CG5183-PC; ER lumen protein retaining receptor 2; KDEL-receptor; KdelR-PA; KdelR-PB; KdelR-PC; lethal (2) 31Em

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The following sections contain reference sequences that belong to a specific genome build. Explain