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Klp31E Kinesin-like protein at 31E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34422, updated on 4-Jan-2025

Summary

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Official Symbol
Klp31Eprovided by FlyBase
Official Full Name
Kinesin-like protein at 31Eprovided by FlyBase
Primary source
FLYBASE:FBgn0032243
Locus tag
Dmel_CG5300
See related
AllianceGenome:FB:FBgn0032243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5300; DmCG5300; Dmel\CG5300; DmKlp31D; DmKlp31E; KIF 21A; KIF21A/B; KLP31E
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 1. Orthologous to human KIF21A (kinesin family member 21A) and KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Klp31E in Genome Data Viewer
Location:
31E1-31E1; 2-42 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10414017..10418991)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10414017..10418991)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S27A Neighboring gene Intronic Protein 259 Neighboring gene uncharacterized protein Neighboring gene Replication factor C subunit 3 Neighboring gene pineapple eye

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1. Chan WM, et al. BMC Genet, 2007 May 18. PMID 17511870, Free PMC Article
  2. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Yamada K, et al. Nat Genet, 2003 Dec. PMID 14595441
  3. Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells. Deng Q, et al. EMBO J, 2021 Oct 1. PMID 34368973, Free PMC Article
  4. A kinesin family tree. Kim AJ, et al. J Cell Sci, 2000 Nov. PMID 11034894
  5. A new kinesin tree. Dagenbach EM, et al. J Cell Sci, 2004 Jan 1. PMID 14657268

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Kinesin-like protein at 31E
Names
CG5300-PA
CG5300-PB
CG5300-PC
CG5300-PE
Kinesin3D
Klp31E-PA
Klp31E-PB
Klp31E-PC
Klp31E-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10414017..10418991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135554.3 → NP_609398.2  Kinesin-like protein at 31E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609398.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NGN7, Q9VKW4
    Related
    FBpp0079608
    Conserved Domains (4) summary
    smart00129
    Location:13 → 370
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:12 → 364
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam14662
    Location:409 → 589
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl02569
    Location:685 → 750
    RasGAP; Ras GTPase Activating Domain

  2. NM_001169466.2 → NP_001162937.2  Kinesin-like protein at 31E, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162937.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHE1, Q9NGN7
    Conserved Domains (3) summary
    smart00129
    Location:13 → 370
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:12 → 364
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    cl02569
    Location:684 → 749
    RasGAP; Ras GTPase Activating Domain

  3. NM_001169465.2 → NP_001162936.1  Kinesin-like protein at 31E, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162936.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NGN7, Q9VKW4
    Conserved Domains (4) summary
    smart00129
    Location:13 → 370
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:12 → 364
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam14662
    Location:409 → 589
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl02569
    Location:685 → 750
    RasGAP; Ras GTPase Activating Domain

  4. NM_001169464.1 → NP_001162935.1  Kinesin-like protein at 31E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162935.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NGN7, Q9VKW4
    Conserved Domains (4) summary
    smart00129
    Location:13 → 370
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01372
    Location:12 → 364
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam14662
    Location:409 → 589
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cl02569
    Location:685 → 750
    RasGAP; Ras GTPase Activating Domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHE1 E1JHE1
Q9NGN7 Q9NGN7
Q9VKW4 Q9VKW4

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