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CG5355 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34421, updated on 9-Dec-2024

Summary

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Official Symbol
CG5355provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032242
Locus tag
Dmel_CG5355
See related
AllianceGenome:FB:FBgn0032242
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5355
Summary
Enables carboxylesterase activity. Predicted to be involved in proteolysis. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; central brain primordium; fat body/gonad primordium; and ganglia. Orthologous to human PREP (prolyl endopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG5355 in Genome Data Viewer
Location:
31E1-31E1; 2-42 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10410537..10413463, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10410537..10413463, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 31a Neighboring gene Ribosomal protein S27A Neighboring gene Intronic Protein 259 Neighboring gene Kinesin-like protein at 31E Neighboring gene Replication factor C subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472
  2. Targets of microRNA regulation in the Drosophila oocyte proteome. Nakahara K, et al. Proc Natl Acad Sci U S A, 2005 Aug 23. PMID 16099838, Free PMC Article
  3. Proteomic profiling in Drosophila reveals potential Dube3a regulation of the actin cytoskeleton and neuronal homeostasis. Jensen L, et al. PLoS One, 2013. PMID 23626758, Free PMC Article
  4. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Bourquard T, et al. Nat Commun, 2023 May 13. PMID 37179358, Free PMC Article
  5. High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration. Al-Ramahi I, et al. Cell Syst, 2018 Jul 25. PMID 29936182, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carboxylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oligopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5355-PA
NP_609397.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10410537..10413463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135553.4 → NP_609397.2  uncharacterized protein Dmel_CG5355 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609397.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961N7, Q9VKW5
    Related
    FBpp0079637
    Conserved Domains (3) summary
    COG0657
    Location:442 → 750
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00326
    Location:541 → 752
    Peptidase_S9; Prolyl oligopeptidase family
    pfam02897
    Location:51 → 467
    Peptidase_S9_N; Prolyl oligopeptidase, N-terminal beta-propeller domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961N7 Q961N7
Q9VKW5 Q9VKW5

Gene LinkOut

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