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Ip259 Intronic Protein 259 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34419, updated on 9-Dec-2024

Summary

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Official Symbol
Ip259provided by FlyBase
Official Full Name
Intronic Protein 259provided by FlyBase
Primary source
FLYBASE:FBgn0025366
Locus tag
Dmel_CG5277
See related
AllianceGenome:FB:FBgn0025366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5277; Dmel\CG5277; IP259
Summary
Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Orthologous to human NSA2 (NSA2 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ip259 in Genome Data Viewer
Location:
31E1-31E1; 2-42 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10408352..10409610)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10408352..10409610)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene uncharacterized protein Neighboring gene Like Sm protein 4 Neighboring gene Ionotropic receptor 31a Neighboring gene Ribosomal protein S27A Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 31E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and expression of the Drosophila ubiquitin-80-amino-acid fusion-protein gene. Barrio R, et al. Biochem J, 1994 Aug 15. PMID 8068011, Free PMC Article
  2. Unique gene organization: alternative splicing in Drosophila produces two structurally unrelated proteins. Mottus RC, et al. Gene, 1997 Oct 1. PMID 9370286
  3. An in vivo RNAi mini-screen in Drosophila cancer models reveals novel potential Wnt targets in liver cancer. Even İ, et al. Turk J Gastroenterol, 2019 Feb. PMID 30541713, Free PMC Article
  4. The bHLH Transcription Factor Hand Regulates the Expression of Genes Critical to Heart and Muscle Function in Drosophila melanogaster. Hallier B, et al. PLoS One, 2015. PMID 26252215, Free PMC Article
  5. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. Okuda K, et al. iScience, 2022 Sep 16. PMID 36060064, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
intronic protein 259
Names
CG5277-PA
CG5277-PB
Ip259-PA
Ip259-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10408352..10409610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058031.5 → NP_477379.1  intronic protein 259, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477379.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76994, Q9VKW7
    Related
    FBpp0079607
    Conserved Domains (1) summary
    cd11381
    Location:4 → 259
    NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)

  2. NM_001273418.1 → NP_001260347.1  intronic protein 259, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260347.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76994, Q9VKW7
    Conserved Domains (1) summary
    cd11381
    Location:4 → 259
    NSA2; pre-ribosomal protein NSA2 (Nop seven-associated 2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76994 O76994

Gene LinkOut

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