Mdh1 Malate dehydrogenase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mdh1provided by FlyBase
Official Full Name: Malate dehydrogenase 1provided by FlyBase
Primary source: FLYBASE:FBgn0262782
Locus tag: Dmel_CG5362
See related: AllianceGenome:FB:FBgn0262782
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5362; cMdh; CT17038; Dmel\CG5362; Mdh; MDH; Mdh-1; MDH-1; MDH1; Mdh2; MdhD; Q9VKX2; sMdh
Summary: Enables L-malate dehydrogenase (NAD+) activity. Involved in NADH metabolic process; malate metabolic process; and oxaloacetate metabolic process. Located in cytosol. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 88. Orthologous to human MDH1 (malate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31E1-31E1; 2-42 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10393774..10396332, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10393774..10396332, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-malate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-malate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-malate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in malate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in malate-aspartate shuttle	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxaloacetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxaloacetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: malate dehydrogenase 1

Names: CG5362-PA; CG5362-PB; Mdh1-PA; Mdh1-PB; cytoplasmic Mdh; cytosolic malate dehydrogenase; malate dehydrogenase; malic DH

NP_001285803.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.37

NP_609394.1

EC 1.-.-.-

EC 1.1.1.-

EC 1.1.1.37

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10393774..10396332 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298874.1 → NP_001285803.1 malate dehydrogenase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285803.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQS7, Q9VKX2

Conserved Domains (2) summary

TIGR01758
Location:6 → 328

MDH_euk_cyt; malate dehydrogenase, NAD-dependent

cd01336
Location:3 → 327

MDH_cytoplasmic_cytosolic; Cytoplasmic and cytosolic Malate dehydrogenases
NM_135550.2 → NP_609394.1 malate dehydrogenase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609394.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQS7, Q9VKX2

Related

FBpp0079640

Conserved Domains (2) summary

TIGR01758
Location:6 → 328

MDH_euk_cyt; malate dehydrogenase, NAD-dependent

cd01336
Location:3 → 327

MDH_cytoplasmic_cytosolic; Cytoplasmic and cytosolic Malate dehydrogenases