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SamDC S-adenosylmethionine decarboxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34396, updated on 4-Jan-2025

Summary

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Official Symbol
SamDCprovided by FlyBase
Official Full Name
S-adenosylmethionine decarboxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0019932
Locus tag
Dmel_CG5029
See related
AllianceGenome:FB:FBgn0019932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5029; Dmel\CG5029; l(2)31Dc; l(2)31Dd; l(2)31De; samdc
Summary
Predicted to enable adenosylmethionine decarboxylase activity. Involved in defense response to Gram-negative bacterium. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See SamDC in Genome Data Viewer
Location:
31D9-31D9; 2-41 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10339457..10341503)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10339457..10341503)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase assembly factor 10 Neighboring gene GATAd Neighboring gene uncharacterized protein Neighboring gene Selenophosphate synthetase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, mapping and mutational analysis of the S-adenosylmethionine decarboxylase gene in Drosophila melanogaster. Larsson J, et al. Mol Gen Genet, 1997 Nov. PMID 9435790
  2. The class 2 selenophosphate synthetase gene of Drosophila contains a functional mammalian-type SECIS. Hirosawa-Takamori M, et al. EMBO Rep, 2000 Nov. PMID 11258485, Free PMC Article
  3. Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase. van Steensel B, et al. Nat Biotechnol, 2000 Apr. PMID 10748524
  4. Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. Tain LS, et al. Aging Cell, 2020 Jan. PMID 31721422, Free PMC Article
  5. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenosylmethionine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylmethionine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
S-adenosylmethionine decarboxylase
Names
CG5029-PA
S-adenosyl decarboxylase
SamDC-PA
NP_477223.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10339457..10341503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057875.5 → NP_477223.2  S-adenosylmethionine decarboxylase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477223.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91925, P91931, Q9VKY9
    UniProtKB/TrEMBL
    Q58CK1
    Related
    FBpp0079584
    Conserved Domains (1) summary
    pfam01536
    Location:6 → 337
    SAM_decarbox; Adenosylmethionine decarboxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91931.1 P91931

Gene LinkOut

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