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CG4972 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34388, updated on 9-Dec-2024

Summary

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Official Symbol
CG4972provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032217
Locus tag
Dmel_CG4972
See related
AllianceGenome:FB:FBgn0032217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4972; Q9VKZ7_DROME
Summary
Predicted to be involved in regulation of signal transduction. Located in endomembrane system. Is expressed in several structures, including Malpighian tubule main body primordium; Malpighian tubule primordium; embryonic/larval midgut primordium; ganglia; and gut section. Orthologous to human NCLN (nicalin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG4972 in Genome Data Viewer
Location:
31D5-31D6; 2-41 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10314792..10317569)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10314792..10317569)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) SH0834 Neighboring gene Ubiquitin specific protease 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonucleoside diphosphate reductase large subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation. Kochanova NY, et al. Nucleic Acids Res, 2020 May 7. PMID 32182352, Free PMC Article
  2. On-bead tryptic proteolysis: an attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. Fukuyama H, et al. J Proteomics, 2012 Aug 3. PMID 22450469
  3. Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. Yatsenko AS, et al. BMC Med, 2020 Jan 21. PMID 31959160, Free PMC Article
  4. Identification of Drosophila centromere associated proteins by quantitative affinity purification-mass spectrometry. Barth TK, et al. Data Brief, 2015 Sep. PMID 26306323, Free PMC Article
  5. Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment. Izutsu M, et al. PLoS One, 2012. PMID 22432011, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4972-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10314792..10317569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135534.3 → NP_609378.1  uncharacterized protein Dmel_CG4972 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZ34, Q9VKZ7
    Related
    FBpp0079578
    Conserved Domains (1) summary
    cd03882
    Location:121 → 429
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MZ34 Q8MZ34
Q9VKZ7 Q9VKZ7

Gene LinkOut

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