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CG5390 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34383, updated on 9-Dec-2024

Summary

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Official Symbol
CG5390provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032213
Locus tag
Dmel_CG5390
See related
AllianceGenome:FB:FBgn0032213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH06341; c-SPH35; cSPH35; Dmel\CG5390; gh06341; SPH; SPH35
Summary
Enables peptidase activator activity. Involved in melanization defense response and zymogen activation. Located in extracellular region. Is expressed in adult head; adult heart; amnioserosa; spermatozoon; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG5390 in Genome Data Viewer
Location:
31D1-31D1; 2-41 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10304069..10306594, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10304069..10306594, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene no mitochondrial derivative Neighboring gene uncharacterized protein Neighboring gene Cdk5 activator-like protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ectopic expression of an endoparasitic wasp venom protein in Drosophila melanogaster affects immune function, larval development and oviposition. Thomas P, et al. Insect Mol Biol, 2010 Aug. PMID 20408903
  2. Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster. Jin Q, et al. Front Immunol, 2023. PMID 37781370, Free PMC Article
  3. Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Connell-Crowley L, et al. Mech Dev, 2007 May. PMID 17368005, Free PMC Article
  4. Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Xue L, et al. Dev Cell, 2007 Sep. PMID 17765686
  5. The instantly released Drosophila immune proteome is infection-specific. Vierstraete E, et al. Biochem Biophys Res Commun, 2004 May 14. PMID 15094375

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster.
    Title: Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in melanization defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in zymogen activation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5390-PA
CG5390-PB
serine protease homologue protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10304069..10306594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135530.3 → NP_609374.1  uncharacterized protein Dmel_CG5390, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609374.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PE8, Q9VL01
    Related
    FBpp0079653
    Conserved Domains (2) summary
    smart00020
    Location:153 → 390
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:153 → 391
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001298873.1 → NP_001285802.1  uncharacterized protein Dmel_CG5390, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285802.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PE8, Q9VL01
    Conserved Domains (2) summary
    smart00020
    Location:153 → 390
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:153 → 391
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86PE8 Q86PE8
Q9VL01 Q9VL01

Gene LinkOut

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