CYLD Cylindromatosis [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CYLDprovided by FlyBase
Official Full Name: Cylindromatosisprovided by FlyBase
Primary source: FLYBASE:FBgn0032210
Locus tag: Dmel_CG5603
See related: AllianceGenome:FB:FBgn0032210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5603; cyld; Cyld; dCYLD; Dmel\CG5603; Q8IPC5
Summary: Enables K63-linked deubiquitinase activity and Met1-linked polyubiquitin deubiquitinase activity. Involved in several processes, including acylglycerol homeostasis; determination of adult lifespan; and regulation of signal transduction. Predicted to be active in cytosol. Is expressed in several structures, including adult fat body; embryonic/larval midgut primordium; ganglia; gonad; and organism subdivision. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 31C7-31D1; 2-41 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10295859..10299847, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10295859..10299847, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the role of CYLD in development, tissue homeostasis, and tumorigenesis
Title: The tumor suppressor CYLD controls epithelial morphogenesis and homeostasis by regulating mitotic spindle behavior and adherens junction assembly.
CYLD negatively regulates Hippo signaling by limiting Hpo phosphorylation.
Title: CYLD negatively regulates Hippo signaling by limiting Hpo phosphorylation in Drosophila.
Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila.
Title: Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila.
CYLD in a broad range of functions associated with fat homeostasis and host defence in Drosophila.
Title: A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c10298695-10298604 mobile_element_type = transposon:INE-1{}6201

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables Met1-linked polyubiquitin deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acylglycerol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein K63-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: cylindromatosis

Names: CG5603-PB; CG5603-PD; CG5603-PE; CYLD-PB; CYLD-PD; CYLD-PE; cylindromatosis ortholog

NP_609371.2

EC 3.4.19.12

NP_723554.1

EC 3.4.19.12

NP_723556.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10295859..10299847 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164909.2 → NP_723554.1 cylindromatosis, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723554.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPC5, Q8SYF0

Related

FBpp0079659

Conserved Domains (2) summary

smart01052
Location:143 → 219

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:276 → 631

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
NM_135527.3 → NP_609371.2 cylindromatosis, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609371.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPC5, Q8SYF0

Related

FBpp0079660

Conserved Domains (2) summary

smart01052
Location:143 → 219

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:276 → 631

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
NM_164911.2 → NP_723556.1 cylindromatosis, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723556.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPC3, Q8SYF0

Related

FBpp0079661

Conserved Domains (2) summary

smart01052
Location:55 → 131

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:188 → 543

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...