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trk trunk [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34376, updated on 9-Dec-2024

Summary

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Official Symbol
trkprovided by FlyBase
Official Full Name
trunkprovided by FlyBase
Primary source
FLYBASE:FBgn0003751
Locus tag
Dmel_CG5619
See related
AllianceGenome:FB:FBgn0003751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5619; Dmel\CG5619; fs(2)trunk; grk; Trk
Summary
Enables receptor ligand activity; torso binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Involved in terminal region determination and torso signaling pathway. Located in extracellular space. Is expressed in nurse cell and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See trk in Genome Data Viewer
Location:
31B1-31B1; 2-40 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10271443..10272324, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10271443..10272324, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Multi-substrate lipid kinase Neighboring gene Utx histone demethylase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The torso ligand, unmasked? Stein D, et al. Sci STKE, 2001 Sep 4. PMID 11752676
  2. Noggin proteins are multifunctional extracellular regulators of cell signaling. Karunaraj P, et al. Genetics, 2022 May 5. PMID 35357435, Free PMC Article
  3. Torso RTK controls Capicua degradation by changing its subcellular localization. Grimm O, et al. Development, 2012 Nov. PMID 23048183, Free PMC Article
  4. Signaling gradients in cascades of two-state reaction-diffusion systems. Berezhkovskii AM, et al. Proc Natl Acad Sci U S A, 2009 Jan 27. PMID 19147842, Free PMC Article
  5. Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like. Henstridge MA, et al. Nat Commun, 2014 Mar 3. PMID 24584029

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Torso interacts with both Trunk and Torso-like, which cooperate to mediate dimerization and activation of Torso at the ends of the Drosophila embryo
    Title: Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torso-like in receptor activation.
  2. Present and other previous studies, suggest that the function of Tsl is to mediate secretion of Trk, thus providing the mechanism for spatially restricted activation of Tor in Drosophila embryos.
    Title: Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini.
  3. Data favours a scenario where Tsl functions post proteolytic processing of Trk to control localized terminal patterning.
    Title: Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like.
  4. Extracellular processing of the Trunk ligand at the anterior and posterior termini of the developing embryo activates the signaling pathway that defines the two ends.
    Title: The torso ligand, unmasked?
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables torso binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in terminal region determination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in terminal region determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in torso signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in torso signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in torso signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
trunk
Names
CG5619-PA
trk-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10271443..10272324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057419.3 → NP_476767.2  trunk [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476767.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24155, Q9VL09
    Related
    FBpp0079667
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24155.1 Q24155

Gene LinkOut

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