Sur Sulfonylurea receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Surprovided by FlyBase
Official Full Name: Sulfonylurea receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0028675
Locus tag: Dmel_CG5772
See related: AllianceGenome:FB:FBgn0028675
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:CK00325; CG5772; CK00325; Dmel\CG5772; Dme_CG5772; DmSUR; dsur; dSur; dSUR; Dsur; DSur; sur; SUR
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to hypoxia. Predicted to be active in membrane. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; cardiogenic mesoderm; dorsal vessel wall cell; and gland. Human ortholog(s) of this gene implicated in several diseases, including dilated cardiomyopathy (multiple); familial atrial fibrillation; glucose metabolism disease (multiple); hypertrichotic osteochondrodysplasia Cantu type; and intellectual disability and myopathy syndrome. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8) and ABCC9 (ATP binding cassette subfamily C member 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10182557..10199117, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10182557..10199117, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Sur is dispensable for chitin synthesis in Drosophila melanogaster embryos.
Title: The sulfonylurea receptor Sur is dispensable for chitin synthesis in Drosophila melanogaster embryos.
In Drosophila melanogaster, suppression of dSUR by RNA interference similarly causes hypersensitivity to infection by flock house virus.
Title: ATP-sensitive potassium channels mediate survival during infection in mammals and insects.
dSUR is regulated by tinman and plays a protective role against hypoxic stress and pacing-induced heart failure
Title: The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT involved_in chitin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_001334732.1

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The following sections contain reference sequences that belong to a specific genome build. Explain