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CG5846 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34326, updated on 4-Jan-2025

Summary

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Official Symbol
CG5846provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032171
Locus tag
Dmel_CG5846
See related
AllianceGenome:FB:FBgn0032171
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5846
Summary
Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Is expressed in adult fat body. Human ortholog(s) of this gene implicated in severe combined immunodeficiency. Orthologous to several human genes including RFXANK (regulatory factor X associated ankyrin containing protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG5846 in Genome Data Viewer
Location:
30F2-30F2; 2-38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9956175..9957237, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9956175..9957019, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45949 Neighboring gene mir-87 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44872 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43683

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis. Tan WJ, et al. BMC Biol, 2024 Jan 2. PMID 38167120, Free PMC Article
  2. LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila. Marcogliese PC, et al. Hum Mol Genet, 2017 Apr 1. PMID 28158614, Free PMC Article
  3. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860
  4. The circadian clock interacts with metabolic physiology to influence reproductive fitness. Xu K, et al. Cell Metab, 2011 Jun 8. PMID 21641546, Free PMC Article
  5. Long-Term Memory in Drosophila Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9. Schwartz S, et al. Genetics, 2016 Jul. PMID 27182943, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5846-PA
CG5846-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9956175..9957237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135489.4 → NP_609333.1  uncharacterized protein Dmel_CG5846, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609333.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VL58
    Related
    FBpp0079487
    Conserved Domains (3) summary
    cd00204
    Location:94 → 218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:104 → 196
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:99 → 130
    ANK; ANK repeat [structural motif]

  2. NM_001316389.1 → NP_001303318.1  uncharacterized protein Dmel_CG5846, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VL58
    Conserved Domains (3) summary
    cd00204
    Location:94 → 218
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:104 → 196
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:99 → 130
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VL58 Q9VL58

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