pelo pelota [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: peloprovided by FlyBase
Official Full Name: pelotaprovided by FlyBase
Primary source: FLYBASE:FBgn0011207
Locus tag: Dmel_CG3959
See related: AllianceGenome:FB:FBgn0011207
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3959; Dmel\CG3959; DmPelota; ms(2)01559; Pelo; PELO; Pelo Hbs1
Summary: Predicted to enable RNA endonuclease activity. Involved in several processes, including female germ-line stem cell asymmetric division; male germ-line stem cell population maintenance; and spermatogenesis. Located in cytoplasm and nucleus. Part of Dom34-Hbs1 complex. Is expressed in adult head. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 30C5-30C5; 2-36 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9700810..9708883)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9700810..9708883)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.
Title: Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.
The evolutionarily conserved Pelo (Dom34)-Hbs1 mRNA surveillance complex is required for transposon silencing in the Drosophila germline.
Title: The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline.
data demonstrated that pelo is a host factor that is required for high efficiency translation of viral capsids and targeting pelo could be a strategy for general inhibition of viral infection.
Title: pelo is required for high efficiency viral replication.
Pelo controls GSC self-renewal by repressing a Bam-independent differentiation pathway possibly through regulating translation.
Title: Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA surveillance	IEA Inferred from Electronic Annotation more info
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic nuclear membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nonfunctional rRNA decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, no-go decay	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay	IEA Inferred from Electronic Annotation more info
involved_in post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm individualization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatocyte division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatocyte division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Dom34-Hbs1 complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pelota

Names: CG3959-PA; pelo-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9700810..9708883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057634.5 → NP_476982.1 pelota [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476982.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48612, Q9VL97

Related

FBpp0079444

Conserved Domains (4) summary

COG1537
Location:1 → 371

PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]

pfam03463
Location:1 → 128

eRF1_1; eRF1 domain 1

pfam03464
Location:136 → 268

eRF1_2; eRF1 domain 2

pfam03465
Location:271 → 370

eRF1_3; eRF1 domain 3