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numb - numb

Enables Notch binding activity. Involved in several processes, including Malpighian tubule tip cell differentiation; negative regulation of macromolecule metabolic process; and neurogenesis. Located in cell cortex. Is expressed in several structures, including Malpighian tubule tip cell primordium; VUM4 interneuron; anlage in statu nascendi; epithelium; and somatic precursor cell. Used to study brain cancer. Orthologous to several human genes including NUMB (NUMB endocytic adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa