U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

numb numb [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34263, updated on 9-Dec-2024

Summary

Official Symbol
numbprovided by FlyBase
Official Full Name
numbprovided by FlyBase
Primary source
FLYBASE:FBgn0002973
Locus tag
Dmel_CG3779
See related
AllianceGenome:FB:FBgn0002973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3779; d-numb; Dmel\CG3779; dNumb; l(2)03235; l(2)3235; l(2)s2201; N7-1; nb; Nb; Numb; NUMB; numbs
Summary
Enables Notch binding activity. Involved in several processes, including Malpighian tubule tip cell differentiation; negative regulation of macromolecule metabolic process; and neurogenesis. Located in cell cortex. Is expressed in several structures, including Malpighian tubule tip cell primordium; anlage in statu nascendi; epithelium; somatic precursor cell; and visceral mesoderm derivative. Used to study brain cancer. Orthologous to several human genes including NUMB (NUMB endocytic adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See numb in Genome Data Viewer
Location:
30B3-30B5; 2-35 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9437469..9464184)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9437469..9464184)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene scattered Neighboring gene Ribosomal protein S28-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43769 Neighboring gene GDP dissociation inhibitor

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Notch binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Malpighian tubule tip cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic heart tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in enteroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroblast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pericardial nephrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory organ precursor cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory organ precursor cell fate determination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory organ precursor cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in basal part of cell TAS
Traceable Author Statement
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
numb
Names
CG3779-PA
CG3779-PB
CG3779-PD
d-Numb
numb-PA
numb-PB
numb-PD

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    9437469..9464184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164855.2NP_723460.1  numb, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723460.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16554
    Related
    FBpp0079419
    Conserved Domains (2) summary
    cd01268
    Location:26160
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:228333
    NumbF; NUMB domain
  2. NM_001273362.1NP_001260291.1  numb, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260291.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B8A413, B8A419, P16554, Q8IPE9, Q961A6, Q9VLB8
    UniProtKB/TrEMBL
    M9PCN6
    Conserved Domains (2) summary
    cd01268
    Location:67201
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:269374
    NumbF; NUMB domain
  3. NM_078799.3NP_523523.2  numb, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523523.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B8A413, B8A419, P16554, Q8IPE9, Q961A6, Q9VLB8
    UniProtKB/TrEMBL
    M9PCN6
    Related
    FBpp0079420
    Conserved Domains (2) summary
    cd01268
    Location:67201
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:269374
    NumbF; NUMB domain