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Try29F Trypsin 29F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34226, updated on 9-Dec-2024

Summary

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Official Symbol
Try29Fprovided by FlyBase
Official Full Name
Trypsin 29Fprovided by FlyBase
Primary source
FLYBASE:FBgn0015316
Locus tag
Dmel_CG9564
See related
AllianceGenome:FB:FBgn0015316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9564; Dmel\CG9564; SP106; try29F; try29F.2; trypsin29F
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in embryonic/larval midgut. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS3P2 (PRSS3 pseudogene 2); PRSS1 (serine protease 1); and PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Try29F in Genome Data Viewer
Location:
29F7-29F7; 2-34 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8998537..8999816)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8998537..8999816)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene alien Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rcd-1 related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Try29F, a new member of the Drosophila trypsin-like protease gene family, is specifically expressed in the posterior embryonic midgut. Paululat A. Gene, 1996 Jun 26. PMID 8682311
  2. The mesodermal expression of rolling stone (rost) is essential for myoblast fusion in Drosophila and encodes a potential transmembrane protein. Paululat A, et al. J Cell Biol, 1997 Jul 28. PMID 9230076, Free PMC Article
  3. The Drosophila gene alien is expressed in the muscle attachment sites during embryogenesis and encodes a protein highly conserved between plants, Drosophila and vertebrates. Goubeaud A, et al. Mech Dev, 1996 Jun. PMID 8817453
  4. High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae. Wang M, et al. Dev Cell, 2022 May 23. PMID 35512700
  5. Drosophila in asthma research. Roeder T, et al. Am J Respir Crit Care Med, 2009 Jun 1. PMID 19342413

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables serine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
trypsin 29F
Names
CG9564-PC
CG9564-PD
Try29F-PC
Try29F-PD
NP_001285772.1
NP_523518.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8998537..8999816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298843.1 → NP_001285772.1  trypsin 29F, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DMZ7, Q9VLF5
    Conserved Domains (2) summary
    smart00020
    Location:41 → 261
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42 → 264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_078794.3 → NP_523518.2  trypsin 29F, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523518.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DMZ7, Q9VLF5
    Related
    FBpp0290879
    Conserved Domains (2) summary
    smart00020
    Location:41 → 261
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:42 → 264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24091 Q24091
Q9VLF5 Q9VLF5

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