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PrBP Prenyl-binding protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34196, updated on 4-Jan-2025

Summary

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Official Symbol
PrBPprovided by FlyBase
Official Full Name
Prenyl-binding proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032059
Locus tag
Dmel_CG9296
See related
AllianceGenome:FB:FBgn0032059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9296; Dmel\CG9296; DmPrBP; DmPrBP/delta
Summary
Predicted to be involved in sensory perception of light stimulus. Located in cytoplasm and nucleus. Is expressed in dorsal pharyngeal muscle cell; larval muscle system; and organism. Human ortholog(s) of this gene implicated in Joubert syndrome 22. Orthologous to human PDE6D (phosphodiesterase 6D). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See PrBP in Genome Data Viewer
Location:
29E3-29E3; 2-33 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8684823..8685955, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8684823..8685955, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Aspartic acid-GTC 1-8 Neighboring gene transfer RNA:Aspartic acid-GTC 1-9 Neighboring gene uncharacterized protein Neighboring gene TRAPP subunit 23 Neighboring gene Hepatocyte nuclear factor 4 Neighboring gene antisense RNA:CR44992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Day JP, et al. Biochem J, 2008 Sep 15. PMID 18503409
  2. Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. Kobayashi M, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16971484, Free PMC Article
  3. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Palanker L, et al. Cell Metab, 2009 Mar. PMID 19254568, Free PMC Article
  4. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Kumar S, et al. Sci Rep, 2016 Nov 7. PMID 27819340, Free PMC Article
  5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in sensory perception of light stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Prenyl-binding protein
Names
CG9296-PA
PrBP-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8684823..8685955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135402.3 → NP_609246.1  Prenyl-binding protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609246.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VLJ0
    UniProtKB/TrEMBL
    A0A1B2AJR5
    Related
    FBpp0079352
    Conserved Domains (1) summary
    pfam05351
    Location:11 → 150
    GMP_PDE_delta; GMP-PDE, delta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLJ0.1 Q9VLJ0

Gene LinkOut

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Chemical Information
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