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Uba4 Ubiquitin-like activating enzyme 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34187, updated on 4-Jan-2025

Summary

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Official Symbol
Uba4provided by FlyBase
Official Full Name
Ubiquitin-like activating enzyme 4provided by FlyBase
Primary source
FLYBASE:FBgn0032054
Locus tag
Dmel_CG13090
See related
AllianceGenome:FB:FBgn0032054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13090; Dmel\CG13090; dMoaD; Mocs3
Summary
Predicted to enable URM1 activating enzyme activity; nucleotidyltransferase activity; and sulfurtransferase activity. Involved in molybdopterin cofactor biosynthetic process and protein urmylation. Located in cytoplasm. Orthologous to human MOCS3 (molybdenum cofactor synthesis 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Uba4 in Genome Data Viewer
Location:
29D4-29D4; 2-33 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8517411..8519176)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8517411..8519176)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class U Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene Sgroppino Neighboring gene Angiotensin-converting enzyme-related Neighboring gene lemming B Neighboring gene lemming A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Urm1: an essential regulator of JNK signaling and oxidative stress in Drosophila melanogaster. Khoshnood B, et al. Cell Mol Life Sci, 2016 May. PMID 26715182, Free PMC Article
  2. A metazoan ATAC acetyltransferase subunit that regulates mitogen-activated protein kinase signaling is related to an ancient molybdopterin synthase component. Suganuma T, et al. Mol Cell Proteomics, 2012 May. PMID 22345504, Free PMC Article
  3. The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia. Otto N, et al. Nat Commun, 2018 Aug 29. PMID 30158546, Free PMC Article
  4. Uba1 functions in Atg7- and Atg3-independent autophagy. Chang TK, et al. Nat Cell Biol, 2013 Sep. PMID 23873149, Free PMC Article
  5. An Interaction Network of RNA-Binding Proteins Involved in Drosophila Oogenesis. Bansal P, et al. Mol Cell Proteomics, 2020 Sep. PMID 32554711, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables URM1 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin-synthase sulfurtransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in molybdopterin cofactor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein urmylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein urmylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA thio-modification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble position uridine thiolation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of molybdopterin adenylyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Ubiquitin-like activating enzyme 4
Names
CG13090-PA
CG13090-PB
CG13090-PC
Uba4 homologue
Uba4 ortholog
Uba4-PA
Uba4-PB
Uba4-PC
ubiquitin activating enzyme 4
NP_001260255.1
NP_001260256.1
NP_609240.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8517411..8519176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273327.1 → NP_001260256.1  Ubiquitin-like activating enzyme 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260256.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T486, Q9VLJ8
    UniProtKB/TrEMBL
    M9PCK7
    Conserved Domains (3) summary
    PRK07878
    Location:56 → 453
    PRK07878; molybdopterin biosynthesis-like protein MoeZ; Validated
    cd00757
    Location:71 → 299
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
    cd01526
    Location:336 → 453
    RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...

  2. NM_135396.3 → NP_609240.2  Ubiquitin-like activating enzyme 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609240.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T486, Q9VLJ8
    UniProtKB/TrEMBL
    M9PCK7
    Related
    FBpp0079295
    Conserved Domains (3) summary
    PRK07878
    Location:56 → 453
    PRK07878; molybdopterin biosynthesis-like protein MoeZ; Validated
    cd00757
    Location:71 → 299
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
    cd01526
    Location:336 → 453
    RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...

  3. NM_001273326.1 → NP_001260255.1  Ubiquitin-like activating enzyme 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260255.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T486, Q9VLJ8
    UniProtKB/TrEMBL
    M9PCK7
    Conserved Domains (3) summary
    PRK07878
    Location:56 → 453
    PRK07878; molybdopterin biosynthesis-like protein MoeZ; Validated
    cd00757
    Location:71 → 299
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
    cd01526
    Location:336 → 453
    RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCK7 M9PCK7
Q9VLJ8.1 Q9VLJ8

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