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prg piragua [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34177, updated on 9-Dec-2024

Summary

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Official Symbol
prgprovided by FlyBase
Official Full Name
piraguaprovided by FlyBase
Primary source
FLYBASE:FBgn0285971
Locus tag
Dmel_CG9233
See related
AllianceGenome:FB:FBgn0285971
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9233; Dmel\CG9233; FU12; fu2; pra; Prg
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dorsal closure and head involution. Predicted to be located in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germ layer; germline cell; and imaginal disc. Orthologous to human ZNF646 (zinc finger protein 646). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See prg in Genome Data Viewer
Location:
29D1-29D1; 2-33 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8464488..8466694)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8464488..8466694)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Aminoadipate-semialdehyde dehydrogenase Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene dachs Neighboring gene transfer RNA:Aspartic acid-GTC 1-2 Neighboring gene Chemosensory protein A 29a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Piragua Gene Is not Essential for Drosophila Development. Sokolov VV, et al. Dokl Biol Sci, 2021 Nov. PMID 34962606
  2. piragua encodes a zinc finger protein required for development in Drosophila. Nazario-Yepiz NO, et al. Mech Dev, 2017 Apr. PMID 28011160
  3. Extremely rapid and reversible optogenetic perturbation of nuclear proteins in living embryos. Kögler AC, et al. Dev Cell, 2021 Aug 23. PMID 34363757, Free PMC Article
  4. GeneFizz: A web tool to compare genetic (coding/non-coding) and physical (helix/coil) segmentations of DNA sequences. Gene discovery and evolutionary perspectives. Yeramian E, et al. Nucleic Acids Res, 2003 Jul 1. PMID 12824434, Free PMC Article
  5. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Rhiner C, et al. Dev Cell, 2010 Jun 15. PMID 20627080

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Piragua Gene Is not Essential for Drosophila Development.
    Title: The Piragua Gene Is not Essential for Drosophila Development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in head involution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
piragua
Names
CG9233-PA
CG9233-PB
fu2
prg-PA
prg-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8464488..8466694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273324.2 → NP_001260253.1  piragua, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260253.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VLK8
    UniProtKB/TrEMBL
    Q9U1J8
    Conserved Domains (5) summary
    COG5048
    Location:212 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:294 → 316
    zf-C2H2; Zinc finger, C2H2 type
    pfam07776
    Location:16 → 94
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam13465
    Location:308 → 331
    zf-H2C2_2; Zinc-finger double domain

  2. NM_135388.5 → NP_609232.2  piragua, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609232.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VLK8
    UniProtKB/TrEMBL
    Q9U1J8
    Related
    FBpp0079289
    Conserved Domains (5) summary
    COG5048
    Location:212 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268 → 288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:294 → 316
    zf-C2H2; Zinc finger, C2H2 type
    pfam07776
    Location:16 → 94
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam13465
    Location:308 → 331
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SZP9 Q8SZP9
Q9U1J8 Q9U1J8
Q9VLK8 Q9VLK8
Q9VLK8.2

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