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CG7627 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34148, updated on 4-Jan-2025

Summary

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Official Symbol
CG7627provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032026
Locus tag
Dmel_CG7627
See related
AllianceGenome:FB:FBgn0032026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
DmCG7627; Dmel\CG7627; Dme_CG7627
Summary
Enables ABC-type heme transporter activity. Involved in heme export. Located in plasma membrane. Is expressed in adult head. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG7627 in Genome Data Viewer
Location:
29B1-29B1; 2-31 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8355678..8362469, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8355678..8362469, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mucin related 29B Neighboring gene Ribosomal protein S13 Neighboring gene COP9 signalosome subunit 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor. Stevens T, et al. Insect Biochem Mol Biol, 2017 Jan. PMID 27914919
  2. Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system. Kim K, et al. Proc Natl Acad Sci U S A, 2020 May 12. PMID 32345720, Free PMC Article
  3. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay JN, et al. Insect Mol Biol, 2004 Oct. PMID 15373810
  4. Signatures of Insecticide Selection in the Genome of Drosophila melanogaster. Duneau D, et al. G3 (Bethesda), 2018 Nov 6. PMID 30190420, Free PMC Article
  5. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. Mayer F, et al. J Neurosci, 2009 Mar 18. PMID 19295159, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type heme transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heme export IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG7627-PA
CG7627-PB
NP_001245943.1
NP_609215.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8355678..8362469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259014.2 → NP_001245943.1  uncharacterized protein Dmel_CG7627, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245943.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DN70, Q9VLN6
    Conserved Domains (4) summary
    cd03244
    Location:1089 → 1310
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:445 → 645
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:12 → 1315
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:815 → 1014
    ABC_membrane; ABC transporter transmembrane region

  2. NM_135371.5 → NP_609215.3  uncharacterized protein Dmel_CG7627, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609215.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DN70, Q9VLN6
    Conserved Domains (4) summary
    cd03244
    Location:1089 → 1310
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:445 → 645
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:12 → 1315
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:815 → 1014
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T9B4 Q8T9B4
Q9VLN6 Q9VLN6

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