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Snx6 Sorting nexin 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34126, updated on 4-Jan-2025

Summary

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Official Symbol
Snx6provided by FlyBase
Official Full Name
Sorting nexin 6provided by FlyBase
Primary source
FLYBASE:FBgn0032005
Locus tag
Dmel_CG8282
See related
AllianceGenome:FB:FBgn0032005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8282; Dmel\CG8282; DmSNX6; Dsnx6; snx6; SNX6
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in phagosome-lysosome fusion involved in apoptotic cell clearance and retrograde transport, endosome to Golgi. Predicted to be located in endosome. Predicted to be part of retromer, tubulation complex. Is expressed in adult head; adult heart; embryonic/larval garland cell; garland cell primordium; and organism. Orthologous to human SNX32 (sorting nexin 32); SNX5 (sorting nexin 5); and SNX6 (sorting nexin 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Snx6 in Genome Data Viewer
Location:
28F3-28F3; 2-30 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8218071..8220741, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8218071..8220741, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PDGF- and VEGF-receptor related Neighboring gene Serpin 28F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Simonetti B, et al. Nat Cell Biol, 2019 Oct. PMID 31576058, Free PMC Article
  2. Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. Koumandou VL, et al. J Cell Sci, 2011 May 1. PMID 21502137, Free PMC Article
  3. Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits. Evangelou A, et al. G3 (Bethesda), 2019 Nov 5. PMID 31540975, Free PMC Article
  4. Mistargeting of secretory cargo in retromer-deficient cells. Neuman SD, et al. Dis Model Mech, 2021 Jan 1. PMID 33380435, Free PMC Article
  5. Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions. Strutt H, et al. Curr Biol, 2019 Feb 4. PMID 30661800, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phagosome-lysosome fusion involved in apoptotic cell clearance IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in positive regulation of Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of retromer, tubulation complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sorting nexin 6
Names
CG8282-PA
CG8282-PB
Snx6-PA
Snx6-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8218071..8220741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135355.4 → NP_609199.1  sorting nexin 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609199.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T083, Q9VLQ9
    Related
    FBpp0079247
    Conserved Domains (2) summary
    cd06892
    Location:72 → 212
    PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
    cd07621
    Location:228 → 446
    BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6

  2. NM_001259010.2 → NP_001245939.1  sorting nexin 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245939.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDI3
    Conserved Domains (2) summary
    cd06892
    Location:72 → 212
    PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
    cd07621
    Location:228 → 452
    BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDI3 M9NDI3
Q9VLQ9 Q9VLQ9

Gene LinkOut

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