U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC5A11 Sodium/solute co-transporter-like 5A11 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34117, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
SLC5A11provided by FlyBase
Official Full Name
Sodium/solute co-transporter-like 5A11provided by FlyBase
Primary source
FLYBASE:FBgn0031998
Locus tag
Dmel_CG8451
See related
AllianceGenome:FB:FBgn0031998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8451; CG8451-PA; Dmel\CG8451
Summary
Predicted to enable symporter activity. Involved in adult feeding behavior and behavioral response to nutrient. Predicted to be located in membrane. Is expressed in several structures, including adult anterior midgut epithelium; adult brain; adult gnathal ganglion; ellipsoid body; and organism subdivision. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SLC5A11 in Genome Data Viewer
Location:
28F1-28F1; 2-30 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8200465..8205132, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8200465..8205132, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44116 Neighboring gene uncharacterized protein Neighboring gene Post-GPI attachment to proteins 5 Neighboring gene antisense RNA:CR44119 Neighboring gene long non-coding RNA:CR44120 Neighboring gene long non-coding RNA:CR44121

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Immediate and delayed effects of nutrient-sensing in fruit fly Drosophila melanogaster. Kahraman A, et al. Behav Processes, 2019 Jul. PMID 31051219
  2. A quantitative feeding assay in adult Drosophila reveals rapid modulation of food ingestion by its nutritional value. Qi W, et al. Mol Brain, 2015 Dec 21. PMID 26692189, Free PMC Article
  3. Drosophila SLC5A11 Mediates Hunger by Regulating K(+) Channel Activity. Park JY, et al. Curr Biol, 2016 Aug 8. PMID 27397890, Free PMC Article
  4. Sex-specific pharmacokinetic response to phytoestrogens in Drosophila melanogaster. Sadova N, et al. Biomed Pharmacother, 2024 Jun. PMID 38663102
  5. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adult feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in behavioral response to nutrient IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Sodium/solute co-transporter-like 5A11
Names
CG8451-PA
NA-dependent multivitamin transporter
SLC5A11-PA
cupcake

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8200465..8205132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135348.3 → NP_609192.1  Sodium/solute co-transporter-like 5A11 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609192.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TZ3, Q9VLR8
    Related
    FBpp0079253
    Conserved Domains (1) summary
    cd11492
    Location:17 → 556
    SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLR8 Q9VLR8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous