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Piezo - piezo

Enables mechanosensitive monoatomic ion channel activity. Involved in several processes, including cellular response to mechanical stimulus; detection of temperature stimulus involved in sensory perception of pain; and mechanosensory behavior. Located in plasma membrane. Is expressed in several structures, including antennal primordium; epithelium; head epidermis primordium; larval imaginal tissue; and sensory neurons. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1; distal arthrogryposis type 3; distal arthrogryposis type 5; and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)) and PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa