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Piezo piezo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34112, updated on 9-Dec-2024

Summary

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Official Symbol
Piezoprovided by FlyBase
Official Full Name
piezoprovided by FlyBase
Primary source
FLYBASE:FBgn0264953
Locus tag
Dmel_CG44122
See related
AllianceGenome:FB:FBgn0264953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.32; CG18103; CG31608; CG44122; CG8486; clone 1.32; Dmel\CG44122; Dmpiezo; DmPiezo; DmPIEZO; fos28F; fos500; OrfKD; piezo
Old locus tag
Dmel_CG18103; Dmel_CG8486
Summary
Enables mechanosensitive monoatomic ion channel activity. Involved in several processes, including cellular response to mechanical stimulus; detection of temperature stimulus involved in sensory perception of pain; and mechanosensory behavior. Located in plasma membrane. Is expressed in several structures, including antennal primordium; epithelium; head epidermis primordium; larval imaginal tissue; and sensory neurons. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1; distal arthrogryposis type 3; distal arthrogryposis type 5; and hereditary lymphedema. Orthologous to human PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)) and PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Piezo in Genome Data Viewer
Location:
28E9-28F1; 2-30 cM
Exon count:
34
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8163073..8190137)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8163073..8190137)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphatidic Acid Phospholipase A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rabenosyn-5 Neighboring gene Acyl-CoA binding protein 1 Neighboring gene antisense RNA:CR44116 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenic Tarantula Toxin: A novel tool to study mechanosensitive ion channels in Drosophila. Beqja D, et al. J Insect Physiol, 2020 Nov-Dec. PMID 32991864, Free PMC Article
  2. Piezo acts as a molecular brake on wound closure to ensure effective inflammation and maintenance of epithelial integrity. Zechini L, et al. Curr Biol, 2022 Aug 22. PMID 35835122, Free PMC Article
  3. Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons. Suslak TJ, et al. PLoS One, 2015. PMID 26186008, Free PMC Article
  4. The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization. Tokusumi Y, et al. Biochem Biophys Res Commun, 2017 May 13. PMID 28342875
  5. Reverse engineering morphogenesis through Bayesian optimization of physics-based models. Kumar N, et al. NPJ Syst Biol Appl, 2024 May 7. PMID 38714708, Free PMC Article

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency.
    Title: Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency.
  2. Control of feeding by Piezo-mediated gut mechanosensation in Drosophila.
    Title: Control of feeding by Piezo-mediated gut mechanosensation in Drosophila.
  3. Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor.
    Title: Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor.
  4. Dissemination of Ras(V12)-transformed cells requires the mechanosensitive channel Piezo.
    Title: Dissemination of Ras(V12)-transformed cells requires the mechanosensitive channel Piezo.
  5. Pzl functions in larval chordotonal neurons to sense proprioceptive information.
    Title: Piezo-like Gene Regulates Locomotion in Drosophila Larvae.
  6. DmPiezo, a Ca(2+)-permeable non-selective cation channel, functions as an intrinsic inhibitor for axon regeneration.
    Title: The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.
  7. Both vertebrate and invertebrate mechanosensitive PIEZO ion channels are polymodal, being voltage modulated, and can even be directly voltage gated following a preceding mechanical stimulus.
    Title: Voltage gating of mechanosensitive PIEZO channels.
  8. demonstration of the existence of a specific group of stem cells in the fly midgut that can directly sense mechanical signals through Piezo
    Title: Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel.
  9. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization. We also demonstrate that the nociception genes encoding the mechanosensory receptors Painless and Piezo, both expressed in class IV neurons, are essential for the normal cellular immune response to parasite challenge.
    Title: The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization.
  10. The mechanosensory channel, Piezo, has been identifieded in larval drosophila dorsal bipolar dendritic sensory neurons, with TRPA1 playing a subsidiary role.
    Title: Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mechanosensitive monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables mechanosensitive monoatomic ion channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
piezo
Names
CG44122-PE
CG44122-PF
CG44122-PG
CG44122-PH
CG44122-PI
CG44122-PJ
CG44122-PK
CG44122-PL
CG44122-PM
CG44122-PO
CG44122-PP
Piezo-PE
Piezo-PF
Piezo-PG
Piezo-PH
Piezo-PI
Piezo-PJ
Piezo-PK
Piezo-PL
Piezo-PM
Piezo-PO
Piezo-PP
dmpiezo
fos-related gene at 28F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8163073..8190137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273297.1 → NP_001260226.1  piezo, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260226.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PF50
    Conserved Domains (2) summary
    pfam12166
    Location:2109 → 2539
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1319 → 1513
    PIEZO; Piezo

  2. NM_164795.6 → NP_723354.3  piezo, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723354.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG4
    Conserved Domains (2) summary
    pfam12166
    Location:2247 → 2677
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1300 → 1494
    PIEZO; Piezo

  3. NM_001042881.5 → NP_001036346.3  piezo, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036346.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8L0
    Conserved Domains (2) summary
    pfam12166
    Location:2209 → 2639
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1300 → 1494
    PIEZO; Piezo

  4. NM_001273298.1 → NP_001260227.1  piezo, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260227.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PB69
    Conserved Domains (2) summary
    pfam12166
    Location:2089 → 2519
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1248 → 1420
    PIEZO; Piezo

  5. NM_001201789.2 → NP_001188718.1  piezo, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188718.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRE5
    Conserved Domains (2) summary
    pfam12166
    Location:2108 → 2538
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1245 → 1439
    PIEZO; Piezo

  6. NM_001316385.1 → NP_001303314.1  piezo, isoform P [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WGQ9
    Conserved Domains (2) summary
    pfam12166
    Location:2511 → 2941
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1226 → 1363
    PIEZO; Piezo

  7. NM_001273300.2 → NP_001260229.2  piezo, isoform O [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCW8
    Conserved Domains (2) summary
    pfam12166
    Location:2376 → 2806
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1226 → 1363
    PIEZO; Piezo

  8. NM_001169436.3 → NP_001162907.1  piezo, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162907.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHB4
    Conserved Domains (2) summary
    pfam12166
    Location:2224 → 2654
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1226 → 1420
    PIEZO; Piezo

  9. NM_001273299.1 → NP_001260228.1  piezo, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCC7
    Conserved Domains (2) summary
    pfam12166
    Location:2071 → 2501
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1226 → 1420
    PIEZO; Piezo

  10. NM_001201790.2 → NP_001188719.1  piezo, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188719.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H6X2P4, M9MSG8
    Conserved Domains (2) summary
    pfam12166
    Location:2089 → 2519
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1226 → 1420
    PIEZO; Piezo

  11. NM_135344.6 → NP_609188.4  piezo, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609188.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VLS3
    Conserved Domains (2) summary
    pfam12166
    Location:2159 → 2589
    Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
    pfam15917
    Location:1245 → 1439
    PIEZO; Piezo
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WGQ9 A0A0S0WGQ9
E1JHB4 E1JHB4
M9MRE5 M9MRE5
M9MSG8.1 M9MSG8
M9PB69 M9PB69
M9PCC7 M9PCC7
M9PCW8 M9PCW8
M9PF50 M9PF50
Q0E8L0 Q0E8L0
Q24436 Q24436
Q8IPG4 Q8IPG4
Q9VLS3 Q9VLS3

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