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CCDC53 Coiled-coil domain containing 53 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34097, updated on 9-Dec-2024

Summary

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Official Symbol
CCDC53provided by FlyBase
Official Full Name
Coiled-coil domain containing 53provided by FlyBase
Primary source
FLYBASE:FBgn0031979
Locus tag
Dmel_CG7429
See related
AllianceGenome:FB:FBgn0031979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ccdc53; Ccdc53; CG7429; Dmel\CG7429
Summary
Involved in nuclear envelope budding and positive regulation of cell adhesion. Located in nucleoplasm. Part of WASH complex. Colocalizes with nuclear envelope. Is expressed in organism. Orthologous to human WASHC3 (WASH complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CCDC53 in Genome Data Viewer
Location:
28D3-28D3; 2-29 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8041106..8041879)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8041106..8041879)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene barrier to autointegration factor Neighboring gene Connector of kinase to AP-1 Neighboring gene ncRNA Neighboring gene Ribosomal protein L36A Neighboring gene Multiple EGF like domains 8 Neighboring gene purity of essence

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding. Davidson KA, et al. J Cell Biol, 2023 Aug 7. PMID 37163553, Free PMC Article
  2. Evolutionary conservation of the WASH complex, an actin polymerization machine involved in endosomal fission. Derivery E, et al. Commun Integr Biol, 2010 May. PMID 20714399, Free PMC Article
  3. Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis. Verboon JM, et al. J Cell Sci, 2018 Apr 13. PMID 29549166, Free PMC Article
  4. Drosophila WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization. Nagel BM, et al. J Cell Sci, 2017 Jan 15. PMID 27884932
  5. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Jia D, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498093, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear envelope budding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of WASH complex IEA
Inferred from Electronic Annotation
more info
  
part_of WASH complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
colocalizes_with nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Coiled-coil domain containing 53
Names
CCDC53-PA
CG7429-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8041106..8041879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135334.5 → NP_609178.1  Coiled-coil domain containing 53 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609178.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SYM1, Q9VLT8
    Related
    FBpp0079162
    Conserved Domains (1) summary
    pfam10152
    Location:28 → 164
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLT8.2 Q9VLT8

Gene LinkOut

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