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Spn28Dc Serpin 28Dc [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34091, updated on 9-Dec-2024

Summary

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Official Symbol
Spn28Dcprovided by FlyBase
Official Full Name
Serpin 28Dcprovided by FlyBase
Primary source
FLYBASE:FBgn0031973
Locus tag
Dmel_CG7219
See related
AllianceGenome:FB:FBgn0031973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7219; Dm-Spn28D; Dmel\CG7219; spn28D; Spn28D
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of melanization defense response; negative regulation of proteolysis; and response to wounding. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including angioedema (multiple); artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to several human genes including SERPINA12 (serpin family A member 12) and SERPINF2 (serpin family F member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Spn28Dc in Genome Data Viewer
Location:
28D3-28D3; 2-29 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8004548..8007210, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8004548..8007210, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44996 Neighboring gene uncharacterized protein Neighboring gene Starvation-upregulated protein Neighboring gene WW domain containing oxidoreductase Neighboring gene uncharacterized protein Neighboring gene Glycine N-acyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Resolving the phylogenetic relationships and evolutionary history of the Drosophila virilis group using multilocus data. Morales-Hojas R, et al. Mol Phylogenet Evol, 2011 Aug. PMID 21571080
  2. A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Colinet D, et al. Dev Comp Immunol, 2009 May. PMID 19109990
  3. Comparative analysis of five immunity-related genes reveals different levels of adaptive evolution in the virilis and melanogaster groups of Drosophila. Morales-Hojas R, et al. Heredity (Edinb), 2009 Jun. PMID 19223926
  4. Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation. Scherfer C, et al. Dev Biol, 2008 Nov 15. PMID 18801354
  5. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of melanization defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
serpin 28Dc
Names
CG7219-PA
Dm-serpin-28D
Serpin-28D
Serpin28Dc
Spn28Dc-PA
serpin 28D

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8004548..8007210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135328.3 → NP_609172.1  serpin 28Dc [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609172.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VLU4
    UniProtKB/TrEMBL
    A4V9T5
    Related
    FBpp0079171
    Conserved Domains (1) summary
    cd00172
    Location:111 → 527
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLU4.2 Q9VLU4

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