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spz3 spatzle 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34077, updated on 9-Dec-2024

Summary

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Official Symbol
spz3provided by FlyBase
Official Full Name
spatzle 3provided by FlyBase
Primary source
FLYBASE:FBgn0031959
Locus tag
Dmel_CG7104
See related
AllianceGenome:FB:FBgn0031959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14533; CG7104; CT21967; CT34263; Dmel\CG7104; Spz-3; Spz3
Summary
Predicted to enable Toll binding activity and growth factor activity. Predicted to be involved in central nervous system formation and innate immune response. Located in extracellular space. Is expressed in adult heart; dorsal pharyngeal muscle cell; larval muscle system; larval somatic muscle cell; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See spz3 in Genome Data Viewer
Location:
28D2-28D2; 2-29 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7873495..7879552, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7873495..7879552, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45364 Neighboring gene transfer RNA:Glycine-GCC 1-3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Small ribonucleoprotein particle protein SmE

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quantifying Glial-Glial Tiling Using Automated Image Analysis in Drosophila. Salazar G, et al. Front Cell Neurosci, 2022. PMID 35401121, Free PMC Article
  2. Retrograde neurotrophin signaling through Tollo regulates synaptic growth in Drosophila. Ballard SL, et al. J Cell Biol, 2014 Mar 31. PMID 24662564, Free PMC Article
  3. Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells. Seong KH, et al. Commun Biol, 2020 May 4. PMID 32367035, Free PMC Article
  4. Evolutionary and functional epitopes of the Spätzle protein: new insights into activation of the Toll receptor. Wang Y, et al. Cell Mol Life Sci, 2009 May. PMID 19308321, Free PMC Article
  5. A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome. Parker JS, et al. Proteins, 2001 Oct 1. PMID 11536362

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spz3 is a novel signaling factor required for maintenance of cortex glial morphology and neuron-glia contact.
    Title: The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function.
  2. Spz3 expression in muscle and proteolytic activation via the Easter protease is necessary and sufficient to promote NMJ growth.
    Title: Retrograde neurotrophin signaling through Tollo regulates synaptic growth in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Toll binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in central nervous system formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
spatzle 3
Names
CG7104-PA
Spz3
spatzle3
spz3-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7873495..7879552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135316.3 → NP_609160.2  spatzle 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609160.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8WTE9, Q9VLV7
    Related
    FBpp0079183
    Conserved Domains (1) summary
    pfam16077
    Location:520 → 607
    Spaetzle; Spaetzle
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLV7.2 Q9VLV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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