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RTL5 retrotransposon Gag like 5 [ Homo sapiens (human) ]

Gene ID: 340526, updated on 27-Nov-2024

Summary

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Official Symbol
RTL5provided by HGNC
Official Full Name
retrotransposon Gag like 5provided by HGNC
Primary source
HGNC:HGNC:29430
See related
Ensembl:ENSG00000242732 MIM:301135; AllianceGenome:HGNC:29430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAR5; MART5; RGAG4; SIRH8; 6430402L03Rik
Expression
Broad expression in brain (RPKM 6.6), testis (RPKM 6.2) and 24 other tissues See more
Orthologs
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Genomic context

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See RTL5 in Genome Data Viewer
Location:
Xq13.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (72127110..72131915, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (70560716..70565521, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (71346960..71351765, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NHS like 2 Neighboring gene RNA, U6 small nuclear 1078, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:71216621-71217222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29753 Neighboring gene Sharpr-MPRA regulatory region 1584 Neighboring gene ribosomal protein S26 pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:71289659-71290216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20902 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29754 Neighboring gene TPT1-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29755 Neighboring gene RNA, 7SL, cytoplasmic 388, pseudogene Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. Ohara O, et al. DNA Res, 2002 Apr 30. PMID 12056414
  2. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Brandt J, et al. Gene, 2005 Jan 17. PMID 15716091
  3. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. Brandt J, et al. Cytogenet Genome Res, 2005. PMID 16093683
  4. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article
  5. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of retrotransposon gag domain containing 4 (RGAG4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA2001

General protein information

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Preferred Names
retrotransposon Gag-like protein 5
Names
Sushi-Ichi retrotransposon homolog 8
mammalian retrotransposon-derived 5
retrotransposon gag domain containing 4
retrotransposon gag domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021352.1 RefSeqGene

    Range
    4987..9792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024455.4 → NP_001019626.1  retrotransposon Gag-like protein 5

    See identical proteins and their annotated locations for NP_001019626.1

    Status: VALIDATED

    Source sequence(s)
    AB082532, BC151224, BX119917
    Consensus CDS
    CCDS55446.1
    UniProtKB/Swiss-Prot
    A7E2W7, Q5HYW3, Q8NCM4, Q9NPX1
    Related
    ENSP00000418667.1, ENST00000479991.1
    Conserved Domains (2) summary
    pfam03732
    Location:190 → 282
    Retrotrans_gag; Retrotransposon gag protein
    pfam16297
    Location:151 → 228
    DUF4939; Domain of unknown function (DUF4939)

  2. NM_001405151.1 → NP_001392080.1  retrotransposon Gag-like protein 5

    Status: VALIDATED

    Source sequence(s)
    BX119917
    UniProtKB/Swiss-Prot
    A7E2W7, Q5HYW3, Q8NCM4, Q9NPX1
    Related
    ENSP00000476792.1, ENST00000609883.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    72127110..72131915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    70560716..70565521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HYW3.1 GenPept UniProtKB/Swiss-Prot:Q5HYW3

Gene LinkOut

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Chemical Information
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