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Tep3 Thioester-containing protein 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34045, updated on 9-Dec-2024

Summary

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Official Symbol
Tep3provided by FlyBase
Official Full Name
Thioester-containing protein 3provided by FlyBase
Primary source
FLYBASE:FBgn0041181
Locus tag
Dmel_CG7068
See related
AllianceGenome:FB:FBgn0041181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7068; Dmel\CG7068; dTEPIII; TEP3; TEP3mel; TepIII; TEPIII
Summary
Predicted to enable endopeptidase inhibitor activity. Involved in defense response to Gram-positive bacterium and innate immune response. Predicted to be located in extracellular space. Is expressed in anterior-posterior subdivision of organism; crop; embryonic/larval plasmatocyte; larval foregut atrium; and larval labral sensory complex. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tep3 in Genome Data Viewer
Location:
28C1-28C1; 2-28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7702805..7710690)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7702805..7710690)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Thioester-containing protein 2 Neighboring gene antisense RNA:CR44990 Neighboring gene transfer RNA:Tyrosine-GTA 1-9 Neighboring gene Neurotransmitter transporter-like Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response. Shokal U, et al. Front Immunol, 2017. PMID 28706521, Free PMC Article
  2. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, et al. EMBO Rep, 2018 May. PMID 29523648, Free PMC Article
  3. Thioester-containing Proteins in the Drosophila melanogaster Immune Response against the Pathogen Photorhabdus. Eleftherianos I, et al. Insects, 2020 Jan 28. PMID 32013030, Free PMC Article
  4. Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Lagueux M, et al. Proc Natl Acad Sci U S A, 2000 Oct 10. PMID 11027343, Free PMC Article
  5. Contrasting evolutionary patterns in Drosophila immune receptors. Jiggins FM, et al. J Mol Evol, 2006 Dec. PMID 17103056, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to other organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Thioester-containing protein 3
Names
CG7068-PA
TEP
Tep3-PA
thiolester containing protein III

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7702805..7710690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078783.3 → NP_523507.2  Thioester-containing protein 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523507.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0U4, Q9NFV6, Q9VLY7
    Related
    FBpp0079101
    Conserved Domains (6) summary
    cd02897
    Location:918 → 1203
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:697 → 787
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:124 → 215
    A2M_N; MG2 domain
    pfam07677
    Location:1313 → 1402
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:967 → 1200
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:448 → 573
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NFV6 Q9NFV6
Q9VLY7 Q9VLY7

Gene LinkOut

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