Mnn1 Menin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mnn1provided by FlyBase
Official Full Name: Menin 1provided by FlyBase
Primary source: FLYBASE:FBgn0031885
Locus tag: Dmel_CG13778
See related: AllianceGenome:FB:FBgn0031885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13778; CG33266; Dmel\CG13778; MEN1; menin; Menin; Menin1; Mnn; mnn1
Summary: Predicted to enable Y-form DNA binding activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including DNA repair; determination of adult lifespan; and regulation of JNK cascade. Located in nucleus. Part of MLL1/2 complex. Is expressed in several structures, including anterior spiracle primordium; anterior-posterior subdivision of organism; and ectoderm. Used to study multiple endocrine neoplasia type 1. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27D7-27D7; 2-24 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7056301..7063586)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7056301..7063586)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here we report the results of our transgenic analysis of this amino acid polymorphism. Genotypes carrying alternative Mnn1 alleles differed in multiple phenotypes in a direction generally consistent with phenotypic differences previously observed along latitudinal clines.
Title: Functional Analysis of a Putative Target of Spatially Varying Selection in the Menin1 Gene of Drosophila melanogaster.
Data show that menin links the stress response to the control of genome stability.
Title: Menin links the stress response to genome stability in Drosophila melanogaster.
We observed complex genetic interactions between mnn1 and jun in different developmental settings. Our data support the idea that one function of menin is to modulate Jun activity in a manner dependent on the cellular context.
Title: Genetic interactions between Drosophila melanogaster menin and Jun/Fos.
Menin has a role in regulating stress response in Drosophila melanogaster
Title: Menin is a regulator of the stress response in Drosophila melanogaster.
Drosophila Mnn1 mutants have an elevated rate of both sporadic and DNA damage-induced mutations.
Title: Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Y-form DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc fusion, thorax closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interstrand cross-link repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G1 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proboscis development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1/2 complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: menin 1

Names: CG13778-PA; CG13778-PB; CG13778-PC; Menin1; Mnn1-PA; Mnn1-PB; Mnn1-PC; menin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

7056301..7063586

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042877.2 → NP_001036342.1 menin 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036342.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KXY9, Q9NKX0, Q9VM47

Conserved Domains (2) summary

cd14456
Location:17 → 464

Menin; Scaffolding protein menin encoded by the MEN1 gene

pfam05053
Location:18 → 714

Menin; Menin
NM_078774.4 → NP_523498.2 menin 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523498.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KXY9, Q9NKX0, Q9VM47

Related

FBpp0079029

Conserved Domains (2) summary

cd14456
Location:17 → 464

Menin; Scaffolding protein menin encoded by the MEN1 gene

pfam05053
Location:18 → 714

Menin; Menin
NM_164739.3 → NP_723252.2 menin 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723252.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8IPI5, Q8SXU2

Related

FBpp0079030

Conserved Domains (1) summary

cd14456
Location:17 → 464

Menin; Scaffolding protein menin encoded by the MEN1 gene