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Gart GART trifunctional enzyme [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33986, updated on 4-Jan-2025

Summary

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Official Symbol
Gartprovided by FlyBase
Official Full Name
GART trifunctional enzymeprovided by FlyBase
Primary source
FLYBASE:FBgn0000053
Locus tag
Dmel_CG31628
See related
AllianceGenome:FB:FBgn0000053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
143062_at; ade3; Ade3; ADE8; CG31628; CG8761; D; Dmel\CG31628; gart; GART; Gart/ade3; l(2)27Da
Summary
Enables phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; and phosphoribosylglycinamide formyltransferase activity. Involved in purine nucleobase biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; embryonic/larval midgut primordium; and gut section. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Gart in Genome Data Viewer
Location:
27D4-27D4; 2-24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7014623..7023898, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7014623..7023898, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uninflatable Neighboring gene long non-coding RNA:CR44326 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Pupal cuticle protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial Magnesium Exporter 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Origin of genes encoding multi-enzymatic proteins in eukaryotes. Davidson JN, et al. Trends Genet, 1997 Jul. PMID 9242051
  2. A Drosophila metabolic gene transcript is alternatively processed. Henikoff S, et al. Cell, 1983 Sep. PMID 6413075
  3. Isolation of a gene from Drosophila by complementation in yeast. Henikoff S, et al. Nature, 1981 Jan 1. PMID 6256646
  4. Multiple purine pathway enzyme activities are encoded at a single genetic locus in Drosophila. Henikoff S, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3080748, Free PMC Article
  5. Cloning exons of mapping of transcription: characterization of the Drosophila melanogaster alcohol dehydrogenase gene. Henikoff S. Nucleic Acids Res, 1983 Jul 25. PMID 6410356, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila.
    Title: Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylamine-glycine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylamine-glycine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylamine-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylamine-glycine ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphoribosylglycinamide formyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylglycinamide formyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylglycinamide formyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in adenine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleobase biosynthetic process IC
Inferred by Curator
more info
 PubMed 
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GART trifunctional enzyme
Names
CG31628-PA
CG31628-PB
CG31628-PC
Gart-PA
Gart-PB
Gart-PC
adenosine 3
complementation group D
NP_001014477.1
NP_001285698.1
NP_523497.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7014623..7023898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298769.1 → NP_001285698.1  GART trifunctional enzyme, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDH3, X2J516
    Conserved Domains (7) summary
    cd02196
    Location:840 → 1123
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:1155 → 1339
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK00885
    Location:4 → 433
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    PRK05385
    Location:442 → 752
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    pfam01071
    Location:108 → 301
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:337 → 430
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 107
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

  2. NM_078773.3 → NP_523497.2  GART trifunctional enzyme, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523497.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDH3, X2J516
    Related
    FBpp0079059
    Conserved Domains (7) summary
    cd02196
    Location:840 → 1123
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:1155 → 1339
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK00885
    Location:4 → 433
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    PRK05385
    Location:442 → 752
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    pfam01071
    Location:108 → 301
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:337 → 430
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 107
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

  3. NM_001014477.2 → NP_001014477.1  GART trifunctional enzyme, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014477.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DZ6
    Conserved Domains (4) summary
    PRK00885
    Location:4 → 433
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    pfam01071
    Location:108 → 301
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:337 → 430
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 107
    GARS_N; Phosphoribosylglycinamide synthetase, N domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00967.2 P00967
Q59DZ6 Q59DZ6
X2J516 X2J516

Gene LinkOut

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