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Nha1 Na[+]/H[+] hydrogen antiporter 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33961, updated on 4-Jan-2025

Summary

Official Symbol
Nha1provided by FlyBase
Official Full Name
Na[+]/H[+] hydrogen antiporter 1provided by FlyBase
Primary source
FLYBASE:FBgn0031865
Locus tag
Dmel_CG10806
See related
AllianceGenome:FB:FBgn0031865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10806; Dmel\CG10806; DmNHA1; nha1; NHA1
Summary
Enables chloride transmembrane transporter activity and sodium:proton antiporter activity. Involved in renal sodium ion transport. Located in brush border. Is expressed in adult Malpighian tubule; adult head; gastric caecum; and gut section. Orthologous to several human genes including SLC9B1 (solute carrier family 9 member B1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Nha1 in Genome Data Viewer
Location:
27C1-27C1; 2-23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6860905..6870389, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6860905..6870389, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Regulator of cyclin A1 Neighboring gene lethal (2) k09022 Neighboring gene long non-coding RNA:CR44915 Neighboring gene long non-coding RNA:CR44914

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables chloride transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:proton antiporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in inorganic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in renal sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Na[+]/H[+] hydrogen antiporter 1
Names
CG10806-PA
CG10806-PB
Nha1-PA
Nha1-PB
serine protease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6860905..6870389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135236.3NP_609080.1  Na[+]/H[+] hydrogen antiporter 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609080.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F2FB79, Q7KTL6
    Related
    FBpp0079001
    Conserved Domains (1) summary
    pfam00999
    Location:249639
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  2. NM_164717.2NP_723224.2  Na[+]/H[+] hydrogen antiporter 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723224.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    F2FB79, Q9VM74
    Related
    FBpp0079002
    Conserved Domains (1) summary
    pfam00999
    Location:256646
    Na_H_Exchanger; Sodium/hydrogen exchanger family