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meng meng-po [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33948, updated on 9-Dec-2024

Summary

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Official Symbol
mengprovided by FlyBase
Official Full Name
meng-poprovided by FlyBase
Primary source
FLYBASE:FBgn0031855
Locus tag
Dmel_CG11221
See related
AllianceGenome:FB:FBgn0031855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11221; Dmel\CG11221; Meng-Po; Pkn; PKN
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in memory and positive regulation of gene expression. Is expressed in adult brain; adult mushroom body; and organism. Orthologous to several human genes including SBK1 (SH3 domain binding kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See meng in Genome Data Viewer
Location:
27A2-27B1; 2-22 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6742502..6756133)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6742502..6756133)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Tubulin tyrosine ligase-like 3B Neighboring gene Tubulin tyrosine ligase-like 3A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Linear Ubiquitin E3 ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Temporally and Spatially Localized PKA Activity within Learning and Memory Circuitry Regulated by Network Feedback. Sears JC, et al. eNeuro, 2022 Mar-Apr. PMID 35301221, Free PMC Article
  2. Use-Dependent, Untapped Dual Kinase Signaling Localized in Brain Learning Circuitry. Sears JC, et al. J Neurosci, 2024 Mar 20. PMID 38267256, Free PMC Article
  3. In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling. Khoo P, et al. Dis Model Mech, 2013 May. PMID 23324326, Free PMC Article
  4. Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia. Warner SJ, et al. J Cell Biol, 2009 Jun 15. PMID 19506041, Free PMC Article
  5. Cellular and molecular organization of the Drosophila foregut. Zhu H, et al. Proc Natl Acad Sci U S A, 2024 Mar 12. PMID 38442150, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in anesthesia-resistant memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in medium-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
meng-po
Names
CG11221-PA
CG11221-PB
Meng-Po
meng-PA
meng-PB
NP_001285688.1
NP_609070.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6742502..6756133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298759.1 → NP_001285688.1  meng-po, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285688.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM90
    Conserved Domains (1) summary
    cd13987
    Location:107 → 366
    STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

  2. NM_135226.3 → NP_609070.1  meng-po, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609070.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM90
    Related
    FBpp0078933
    Conserved Domains (1) summary
    cd13987
    Location:107 → 366
    STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM90.1 Q9VM90

Gene LinkOut

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