U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TTLL3A Tubulin tyrosine ligase-like 3A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33947, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
TTLL3Aprovided by FlyBase
Official Full Name
Tubulin tyrosine ligase-like 3Aprovided by FlyBase
Primary source
FLYBASE:FBgn0031854
Locus tag
Dmel_CG11323
See related
AllianceGenome:FB:FBgn0031854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11323; DmCG11323; Dmel\CG11323; dmTTLL3A; TTLL3
Summary
Enables protein-glycine ligase activity, elongating and protein-glycine ligase activity, initiating. Involved in protein polyglycylation. Located in microtubule cytoskeleton. Orthologous to several human genes including TTLL8 (tubulin tyrosine ligase like 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TTLL3A in Genome Data Viewer
Location:
27A2-27A2; 2-22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6736364..6740188, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6736364..6740188, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Liprin-alpha Neighboring gene Tubulin tyrosine ligase-like 3B Neighboring gene meng-po Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
  2. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
  3. Oviposition behaviour in Drosophila melanogaster: Genetic and behavioural decoupling between oviposition acceptance and preference for natural fruits. Fanara JJ, et al. J Evol Biol, 2023 Jan. PMID 36357966
  4. Drosophila spermiogenesis: Big things come from little packages. Fabian L, et al. Spermatogenesis, 2012 Jul 1. PMID 23087837, Free PMC Article
  5. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-glycine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glycine ligase activity, elongating IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glycine ligase activity, initiating IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glycine ligase activity, initiating IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglycylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tubulin tyrosine ligase-like 3A
Names
CG11323-PA
TTLL3A-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6736364..6740188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135225.2 → NP_609069.1  tubulin tyrosine ligase-like 3A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609069.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VM91
    Related
    FBpp0078935
    Conserved Domains (1) summary
    pfam03133
    Location:342 → 640
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VM91.1 Q9VM91

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools