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Ent2 Equilibrative nucleoside transporter 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33921, updated on 9-Dec-2024

Summary

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Official Symbol
Ent2provided by FlyBase
Official Full Name
Equilibrative nucleoside transporter 2provided by FlyBase
Primary source
FLYBASE:FBgn0263916
Locus tag
Dmel_CG31911
See related
AllianceGenome:FB:FBgn0263916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD04971; CG11045; CG31911; Dmel\CG31911; DmEnt2; DmENT2; ent2; ENT2; LD04971; P124
Summary
Enables nucleoside transmembrane transporter activity. Involved in several processes, including associative learning; negative regulation of calcium ion import; and nucleoside transmembrane transport. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe; adult head; adult optic lobe; adult pars intercerebralis; and synaptic neuropil subdomain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ent2 in Genome Data Viewer
Location:
26E3-26E3; 2-21 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6562325..6564709)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6562325..6564709)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 5B Neighboring gene Cytochrome c oxidase subunit 5B-like Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene uncharacterized protein Neighboring gene Dipeptidyl peptidase 10 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Novel memory mutants in Drosophila: behavioral characteristics of the P-insertional mutant in the Ent2P locus]. Molotova-Besedina NG, et al. Genetika, 2009 Jan. PMID 19239097
  2. Extracellular adenosine mediates a systemic metabolic switch during immune response. Bajgar A, et al. PLoS Biol, 2015 Apr. PMID 25915062, Free PMC Article
  3. Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila. Petitgas C, et al. Elife, 2024 May 3. PMID 38700995, Free PMC Article
  4. Mutation in the Drosophila melanogaster adenosine receptor gene selectively decreases the mosaic hyperplastic epithelial outgrowth rates in wts or dco heterozygous flies. Sidorov R, et al. Purinergic Signal, 2015 Mar. PMID 25528157, Free PMC Article
  5. Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter. Machado J, et al. Physiol Genomics, 2007 Feb 12. PMID 17090699

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results provide first evidence of a role for equilibrative nucleoside transporter 2 function in Drosophila associative learning.
    Title: Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila.
  2. The genetic variability in Ent2 locus should be considered as a factor of risk for development of mental retardation and disorders of visual perception.
    Title: [Novel memory mutants in Drosophila: behavioral characteristics of the P-insertional mutant in the Ent2P locus].
  3. ENT2 has broad substrate specificity, is insensitive to standard nucleoside transport inhibitors and is expressed in the digestive tract of late stage embryos.
    Title: Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nucleoside transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleoside transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IC
Inferred by Curator
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
equilibrative nucleoside transporter 2
Names
CG31911-PA
CG31911-PB
Ent2-PA
Ent2-PB
P124
equilibrative nucleoside transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6562325..6564709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298751.1 → NP_001285680.1  equilibrative nucleoside transporter 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285680.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMB6
    Conserved Domains (1) summary
    cl15430
    Location:62 → 457
    Nucleoside_tran; Nucleoside transporter

  2. NM_135205.4 → NP_609049.1  equilibrative nucleoside transporter 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609049.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMB6
    Related
    FBpp0078920
    Conserved Domains (1) summary
    cl15430
    Location:62 → 457
    Nucleoside_tran; Nucleoside transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMB6 Q9VMB6

Gene LinkOut

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