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COX5B Cytochrome c oxidase subunit 5B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33918, updated on 9-Dec-2024

Summary

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Official Symbol
COX5Bprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 5Bprovided by FlyBase
Primary source
FLYBASE:FBgn0031830
Locus tag
Dmel_CG11015
See related
AllianceGenome:FB:FBgn0031830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey143; anon-WO0118547.187; BcDNA:RH49324; CcO Vb; CG11015; CoVb; cox5B; Cox5b; COXB; COXVb; Dmel\CG11015; Q9VMB9; Vb
Summary
Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; larval muscle cell; and mesoderm. Used to study cytochrome-c oxidase deficiency disease. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See COX5B in Genome Data Viewer
Location:
26E3-26E3; 2-21 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6557800..6559308)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6557800..6559308)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44776 Neighboring gene Intraflagellar transport 52 Neighboring gene Cytochrome c oxidase subunit 5B-like Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene Equilibrative nucleoside transporter 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetically encoded biosensor for visualising hypoxia responses in vivo. Misra T, et al. Biol Open, 2017 Feb 15. PMID 28011628, Free PMC Article
  2. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
  3. Practical Recommendations for the Use of the GeneSwitch Gal4 System to Knock-Down Genes in Drosophila melanogaster. Scialo F, et al. PLoS One, 2016. PMID 27570965, Free PMC Article
  4. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
  5. Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster. Rera M, et al. Mech Ageing Dev, 2010 Feb. PMID 20096722

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial envelope IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 5B
Names
CG11015-PA
CG11015-PB
COX5B-PA
COX5B-PB
cytochrome c oxidase Vb
cytochrome c oxidase polypeptide Vb
cytochrome c oxidase subunit Vb
subunit Vb
succinate-CoA ligase subunit beta

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6557800..6559308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135202.2 → NP_609046.1  cytochrome c oxidase subunit 5B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609046.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMB9
    Related
    FBpp0078918, FBtr0079288
    Conserved Domains (1) summary
    cd00924
    Location:25 → 120
    Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_001298749.1 → NP_001285678.1  cytochrome c oxidase subunit 5B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285678.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMB9
    Conserved Domains (1) summary
    cd00924
    Location:25 → 120
    Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86NN8 Q86NN8
Q9VMB9 Q9VMB9

Gene LinkOut

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