eya eyes absent [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eyaprovided by FlyBase
Official Full Name: eyes absentprovided by FlyBase
Primary source: FLYBASE:FBgn0000320
Locus tag: Dmel_CG9554
See related: AllianceGenome:FB:FBgn0000320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 24582246; BcDNA:LD16029; CG9554; cli; CLI; cli/eya; Clift; CLIFT; cli[eya]; del1; dEYA; Dmel\CG9554; eay; ey-2; EY2-1; Eya; EYA; Eyes absent
Summary: Enables DNA-binding transcription factor binding activity; protein tyrosine phosphatase activity; and transcription coactivator activity. Involved in several processes, including eye morphogenesis; nervous system development; and positive regulation of macromolecule biosynthetic process. Located in cytosol and nucleus. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; head epidermis primordium; somatic cell of ovariole; and somatic trunk mesoderm derivative. Used to study branchiootorenal syndrome and eye disease. Human ortholog(s) of this gene implicated in auditory system disease (multiple); branchiootorenal syndrome (multiple); congestive heart failure; and dilated cardiomyopathy (multiple). Orthologous to several human genes including EYA2 (EYA transcriptional coactivator and phosphatase 2); EYA3 (EYA transcriptional coactivator and phosphatase 3); and EYA4 (EYA transcriptional coactivator and phosphatase 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 26E1-26E2; 2-21 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6527447..6546976, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6527447..6546976, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes.
Title: Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes.
The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.
Title: The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.
EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila.
Title: EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila.
This study showed that the eya2 mutants with disrupted vision showed normal mating effects on sleep.
Title: Mechanisms of sleep plasticity due to sexual experience in Drosophila melanogaster.
speculate that Eya's tyrosine phosphatase activity, although non-essential, confers robustness to RDGN output
Title: Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila.
Uncover a novel role for Eya and So in promoting cell cycle exit in the retinal second mitotic wave (SMW), a synchronized, terminal cell division that occurs several hours after passage of the furrow. We show that Combgap (Cg), a zinc-finger transcription factor, antagonizes Eya-So function in the SMW.
Title: Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina.
By removing gene function in differentiating cells, the study shows that eya is dispensable for larval photoreceptor differentiation, but is required for differentiation during pupal development.
Title: Conditional knockout of retinal determination genes in differentiating cells in Drosophila.
our data provide new insight into the cytoplasmic phosphotyrosine signaling networks that operate during photoreceptor axon guidance and suggest specific points of interaction with Eya.
Title: Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila.
In this report we explore the mechanisms by which eya expression is spatially and temporally governed in the developing eye. We demonstrate that multiple cis-regulatory elements function cooperatively to control eya transcription and that spacing between a pair of enhancer elements is important for maintaining correct gene expression
Title: Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements.
A primary function of Eya during Drosophila eye development is as a transcriptional coactivator.
Title: Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables non-membrane spanning protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity, metal-dependent	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Bolwig's organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye cone cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insect visual primordium formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in photoreceptor cell axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigment cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed
involved_in ventral cord development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eyes absent

Names: CG9554-PA; CG9554-PB; CG9554-PC; Eye absent; Eyes-absent; clift; delayed gonad formation 1; eya-PA; eya-PB; eya-PC; eyeless 2

NP_001245913.1

EC 3.1.3.48

NP_523492.1

EC 3.1.3.48

NP_723188.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6527447..6546976 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078768.4 → NP_523492.1 eyes absent, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523492.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q05201

Related

FBpp0078963

Conserved Domains (2) summary

TIGR01658
Location:486 → 760

EYA-cons_domain; eyes absent protein conserved domain

pfam12446
Location:407 → 479

DUF3682; Protein of unknown function (DUF3682)
NM_164693.2 → NP_723188.1 eyes absent, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723188.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q05201, Q961V4, Q9VMC1

Related

FBpp0078964

Conserved Domains (2) summary

TIGR01658
Location:492 → 766

EYA-cons_domain; eyes absent protein conserved domain

pfam12446
Location:413 → 485

DUF3682; Protein of unknown function (DUF3682)
NM_001258984.1 → NP_001245913.1 eyes absent, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245913.1

Status: REVIEWED

UniProtKB/TrEMBL

M9ND38

Conserved Domains (2) summary

TIGR01658
Location:402 → 676

EYA-cons_domain; eyes absent protein conserved domain

pfam12446
Location:323 → 395

DUF3682; Protein of unknown function (DUF3682)