U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KFase Kynurenine formamidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33907, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
KFaseprovided by FlyBase
Official Full Name
Kynurenine formamidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0287695
Locus tag
Dmel_CG9542
See related
AllianceGenome:FB:FBgn0287695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9542; Dmel\CG9542; Kf2
Summary
Enables arylformamidase activity. Predicted to be involved in tryptophan catabolic process to kynurenine. Is expressed in adult fat body. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See KFase in Genome Data Viewer
Location:
26D9-26D9; 2-20 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6487342..6488756, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6487342..6488756, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Sec61 alpha subunit Neighboring gene long non-coding RNA:CR45463 Neighboring gene Daxx-like protein Neighboring gene Coat Protein (coatomer) epsilon Neighboring gene PHD finger protein 5a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Biochemical and genetic characterization of kynurenine formamidase from Drosophila melanogaster. Moore GP, et al. Biochem Genet, 1978 Aug. PMID 83140
  2. Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Han Q, et al. Biochem J, 2012 Sep 1. PMID 22690733, Free PMC Article
  3. The characterization of multiple forms of kynurenine formidase in Drosophila melanogaster. Moore GP, et al. Biochim Biophys Acta, 1975 Aug 26. PMID 50862
  4. Effect of Kynurenic Acid on Pupae Viability of Drosophila melanogaster cinnabar and cardinal Eye Color Mutants with Altered Tryptophan-Kynurenine Metabolism. Navrotskaya V, et al. Neurotox Res, 2018 Aug. PMID 29619629
  5. Extension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging. Oxenkrug G, et al. Exp Biol Med (Maywood), 2023 Apr. PMID 37300401, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables arylformamidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylformamidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arylformamidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kynurenine formamidase
Names
CG9542-PA
CG9542-PB
KFase-PA
KFase-PB
formamidase
kynurenine formamidase 2
NP_001285676.1
NP_609036.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6487342..6488756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298747.1 → NP_001285676.1  kynurenine formamidase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285676.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMC9
    UniProtKB/TrEMBL
    X2J8X6
    Conserved Domains (1) summary
    COG0657
    Location:67 → 297
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  2. NM_135192.2 → NP_609036.1  kynurenine formamidase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609036.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMC9
    UniProtKB/TrEMBL
    X2J8X6
    Related
    FBpp0078895, FBtr0079265
    Conserved Domains (1) summary
    COG0657
    Location:67 → 297
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMC9.1 Q9VMC9
X2J8X6 X2J8X6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools