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Daxx Daxx-like protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33906, updated on 9-Dec-2024

Summary

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Official Symbol
Daxxprovided by FlyBase
Official Full Name
Daxx-like proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031820
Locus tag
Dmel_CG9537
See related
AllianceGenome:FB:FBgn0031820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9537; DAXX; dlp; DLP; Dmel\CG9537
Summary
Predicted to enable transcription coregulator activity. Involved in several processes, including determination of adult lifespan; positive regulation of DNA-templated transcription; and response to oxidative stress. Located in cytosol and nucleus. Is expressed in larval brain; organism; and wing disc. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Daxx in Genome Data Viewer
Location:
26D8-26D9; 2-20 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6480929..6487576)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6480929..6487576)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sec61 alpha subunit Neighboring gene long non-coding RNA:CR45463 Neighboring gene Kynurenine formamidase Neighboring gene Coat Protein (coatomer) epsilon Neighboring gene PHD finger protein 5a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions. Santiago A, et al. Cell Cycle, 2009 Jan 1. PMID 19106612
  2. Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions. Mauri F, et al. J Biol Chem, 2008 Jul 25. PMID 18492669, Free PMC Article
  3. Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. Bodai L, et al. J Biol Chem, 2007 Dec 14. PMID 17933869
  4. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Yang Y, et al. Nat Commun, 2019 Aug 21. PMID 31434890, Free PMC Article
  5. Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. Sala A, et al. EMBO J, 2011 May 4. PMID 21448136, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DJ-1beta protects flies against oxidative stress- and UV-induced apoptosis by regulating the subcellular localization and gene expression of DLP, thus implying that Daxx-induced apoptosis is involved in the pathogenesis of DJ-1-associated PD.
    Title: Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO.
  2. These results suggest that the conserved SUMO-interacting motifs are involved in mediating protein-protein interactions that underlie Daxx's diverse cellular functions.
    Title: Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions.
  3. Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level
    Title: Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Daxx-like protein
Names
CG9537-PA
CG9537-PB
Daxx-PA
Daxx-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6480929..6487576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135191.3 → NP_609035.2  Daxx-like protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609035.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NNF9, Q9VMD0
    UniProtKB/TrEMBL
    Q8WSS9
    Related
    FBpp0078890
    Conserved Domains (3) summary
    PTZ00449
    Location:278 → 379
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PRK10263
    Location:707 → 892
    PRK10263; DNA translocase FtsK; Provisional
    cd13150
    Location:1276 → 1462
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)

  2. NM_001298746.1 → NP_001285675.1  Daxx-like protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285675.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NNF9, Q9VMD0
    UniProtKB/TrEMBL
    Q8WSS9
    Conserved Domains (3) summary
    PTZ00449
    Location:278 → 379
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PRK10263
    Location:707 → 892
    PRK10263; DNA translocase FtsK; Provisional
    cd13150
    Location:1276 → 1462
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5UDQ8 Q5UDQ8
Q8WSS9 Q8WSS9
Q95TR4 Q95TR4
Q960X2 Q960X2
Q9VMD0.3 Q9VMD0

Gene LinkOut

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