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Rchy1 Ring finger and CHY zinc finger domain containing 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33901, updated on 4-Jan-2025

Summary

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Official Symbol
Rchy1provided by FlyBase
Official Full Name
Ring finger and CHY zinc finger domain containing 1provided by FlyBase
Primary source
FLYBASE:FBgn0031816
Locus tag
Dmel_CG16947
See related
AllianceGenome:FB:FBgn0031816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey20; CG16947; Dmel\CG16947
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in negative regulation of gliogenesis. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in embryonic large intestine and yolk nucleus. Orthologous to human RCHY1 (ring finger and CHY zinc finger domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Rchy1 in Genome Data Viewer
Location:
26D5-26D7; 2-20 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6459015..6465669, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6459015..6465669, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene real-time Neighboring gene farjavit Neighboring gene HemK methyltransferase 1 Neighboring gene mummy

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. miR-31 mutants reveal continuous glial homeostasis in the adult Drosophila brain. Foo LC, et al. EMBO J, 2017 May 2. PMID 28320737, Free PMC Article
  2. Cyclin-dependent kinase 9 is required for the survival of adult Drosophila melanogaster glia. Foo LC. Sci Rep, 2017 Jul 28. PMID 28754981, Free PMC Article
  3. Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics. Reumer A, et al. Dev Comp Immunol, 2009 Nov. PMID 19545586
  4. Genome-wide analysis in Drosophila reveals diet-by-gene interactions and uncovers diet-responsive genes. Francis D, et al. G3 (Bethesda), 2021 Sep 27. PMID 34568906, Free PMC Article
  5. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ring finger and CHY zinc finger domain containing 1
Names
CG16947-PA
CG16947-PB
Rchy1-PA
Rchy1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6459015..6465669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135186.2 → NP_609030.1  ring finger and CHY zinc finger domain containing 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609030.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMD4
    Related
    FBpp0078901
    Conserved Domains (3) summary
    cd00162
    Location:311 → 357
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam05495
    Location:184 → 257
    zf-CHY; CHY zinc finger
    pfam14599
    Location:358 → 416
    zinc_ribbon_6; Zinc-ribbon

  2. NM_001273204.2 → NP_001260133.1  ring finger and CHY zinc finger domain containing 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMD4
    Conserved Domains (3) summary
    cd00162
    Location:311 → 357
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam05495
    Location:184 → 257
    zf-CHY; CHY zinc finger
    pfam14599
    Location:358 → 416
    zinc_ribbon_6; Zinc-ribbon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMD4 Q9VMD4

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