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Acox3 Acyl-CoA oxidase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33898, updated on 9-Dec-2024

Summary

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Official Symbol
Acox3provided by FlyBase
Official Full Name
Acyl-CoA oxidase 3provided by FlyBase
Primary source
FLYBASE:FBgn0031813
Locus tag
Dmel_CG9527
See related
AllianceGenome:FB:FBgn0031813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACOX3; CG9527; Dmel\CG9527; LCAD
Summary
Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to be active in peroxisome. Is expressed in adult head; adult heart; embryonic/larval midgut; embryonic/larval oenocyte; and organism. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Acox3 in Genome Data Viewer
Location:
26D1-26D4; 2-20 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6426724..6448403, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6426724..6448403, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tiggrin Neighboring gene Fic domain-containing protein Neighboring gene real-time Neighboring gene farjavit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endurance exercise upregulates mtp expression in aged Drosophila to ameliorate age-related diastolic dysfunction and extend lifespan. Peng T, et al. Physiol Rep, 2024 Feb. PMID 38307709, Free PMC Article
  2. miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila. Pandey M, et al. Elife, 2021 Jun 8. PMID 34100717, Free PMC Article
  3. dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies. Banerjee KK, et al. Aging (Albany NY), 2012 Mar. PMID 22411915, Free PMC Article
  4. Cardiac Snail family of transcription factors directs systemic lipid metabolism in Drosophila. Liu Y, et al. PLoS Genet, 2019 Nov. PMID 31725726, Free PMC Article
  5. Retrotransposon-gene associations are widespread among D. melanogaster populations. Franchini LF, et al. Mol Biol Evol, 2004 Jul. PMID 15014149

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c6436013-6431564 mobile_element_type = transposon:roo{}315

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pristanoyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Acyl-CoA oxidase 3
Names
Acox3-PA
Acox3-PB
Acox3-PC
Acox3-PD
CG9527-PA
CG9527-PB
CG9527-PC
CG9527-PD
long chain acyl-CoA-dehydrogenase
NP_001137800.1
NP_001260131.1
NP_001285671.1
NP_609027.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6426724..6448403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298742.1 → NP_001285671.1  Acyl-CoA oxidase 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285671.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYT1, Q9VMD7
    Conserved Domains (1) summary
    cl09933
    Location:31 → 673
    ACAD; Acyl-CoA dehydrogenase

  2. NM_001273202.2 → NP_001260131.1  Acyl-CoA oxidase 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260131.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYT1, Q9VMD7
    Conserved Domains (1) summary
    cl09933
    Location:31 → 673
    ACAD; Acyl-CoA dehydrogenase

  3. NM_135183.5 → NP_609027.3  Acyl-CoA oxidase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609027.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYT1, Q9VMD7
    Related
    FBpp0088887
    Conserved Domains (1) summary
    cl09933
    Location:31 → 673
    ACAD; Acyl-CoA dehydrogenase

  4. NM_001144328.2 → NP_001137800.1  Acyl-CoA oxidase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137800.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z028, Q8SYT1
    Conserved Domains (2) summary
    PLN02312
    Location:56 → 682
    PLN02312; acyl-CoA oxidase
    cl09933
    Location:52 → 694
    ACAD; Acyl-CoA dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z028 B7Z028
Q8SYT1 Q8SYT1
Q9VMD7 Q9VMD7

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