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slam slow as molasses [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33890, updated on 9-Dec-2024

Summary

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Official Symbol
slamprovided by FlyBase
Official Full Name
slow as molassesprovided by FlyBase
Primary source
FLYBASE:FBgn0043854
Locus tag
Dmel_CG9506
See related
AllianceGenome:FB:FBgn0043854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9506; Dmel\CG9506; Slam; wdo
Summary
Involved in germ cell migration; plasma membrane invagination; and syncytial embryo cellularization. Located in cellularization cleavage furrow invagination front and cleavage furrow. Is expressed in furrow canal; organism; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See slam in Genome Data Viewer
Location:
26C4-26C4; 2-19 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6372388..6377284)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6372388..6377284)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44778 Neighboring gene Neprilysin-like 4 Neighboring gene Dpr-interacting protein epsilon Neighboring gene Neprilysin-like 5 Neighboring gene Neprilysin-like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plasma membrane flattens out to fuel cell-surface growth during Drosophila cellularization. Figard L, et al. Dev Cell, 2013 Dec 23. PMID 24316147, Free PMC Article
  2. Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir. Figard L, et al. Dev Cell, 2016 May 9. PMID 27165556, Free PMC Article
  3. Localization and translation control of slam in Drosophila cellularization. Yan S, et al. Fly (Austin), 2018. PMID 30211628, Free PMC Article
  4. In Vivo Force Application Reveals a Fast Tissue Softening and External Friction Increase during Early Embryogenesis. D'Angelo A, et al. Curr Biol, 2019 May 6. PMID 31031116, Free PMC Article
  5. Flow-dependent myosin recruitment during Drosophila cellularization requires zygotic dunk activity. He B, et al. Development, 2016 Jul 1. PMID 27226317, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biochemical interaction of slam mRNA and protein as demonstrated by specific co-immunoprecipitation from embryonic lysate. The intimate relationship of slam mRNA and protein may constitute a positive feedback loop that facilitates and controls timely and rapid accumulation of Slam protein at the prospective basal region.
    Title: Slam protein dictates subcellular localization and translation of its own mRNA.
  2. Following the onset of zygotic gene expression, Slam and Nullo together stabilise the retracting metaphase furrow and Slam triggers invagination of the cleavage furrow.
    Title: Function and dynamics of slam in furrow formation in early Drosophila embryo.
  3. Accumulation of slam mRNA and protein at the presumptive invagination site provides a spatial and temporal trigger for RhoGEF2-Rho1 signalling.
    Title: Localization of RhoGEF2 during Drosophila cellularization is developmentally controlled by Slam.
  4. Slam is required for the localization of a signal to the basal side of blastoderm cells that is needed later in the posterior midgut to guide germ cells.
    Title: Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila.
  5. analysis of the slow as molasses (slam) gene provides a potential link between somatic cell formation and germ cell migration
    Title: Germ cell migration: as slow as molasses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cellularization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellularization TAS
Traceable Author Statement
more info
 PubMed 
involved_in cleavage furrow formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cleavage furrow ingression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in membrane organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein localization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in syncytial embryo cellularization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellularization cleavage furrow invagination front IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
slow as molasses
Names
CG9506-PB
CG9506-PC
slam-PB
slam-PC
waldo

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6372388..6377284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135176.3 → NP_609020.3  slow as molasses, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609020.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHJ2, Q9VME5

  2. NM_001298739.1 → NP_001285668.1  slow as molasses, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHJ2, Q9VME5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VME5 Q9VME5

Gene LinkOut

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