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WDR79 WD repeat domain 79 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33865, updated on 9-Dec-2024

Summary

Official Symbol
WDR79provided by FlyBase
Official Full Name
WD repeat domain 79provided by FlyBase
Primary source
FLYBASE:FBgn0031782
Locus tag
Dmel_CG9226
See related
AllianceGenome:FB:FBgn0031782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9226; Dmel\CG9226; dWDR79; p70
Summary
Enables box C/D sno(s)RNA binding activity. Involved in Cajal body organization. Located in Cajal body. Used to study motor neuron disease. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See WDR79 in Genome Data Viewer
Location:
26B7-26B7; 2-18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6125879..6127775, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6125879..6127775, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene stathmin Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 2/3 complex, subunit 4 Neighboring gene tectonic Neighboring gene B9d2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables box C/D sno(s)RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Cajal body organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Cajal body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Cajal body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat domain 79
Names
CG9226-PB
CG9226-PC
WD repeat domain 79 homolog
WDR79-PB
WDR79-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6125879..6127775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298736.1NP_001285665.1  WD repeat domain 79, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285665.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NL34, Q960H9, Q9VMH1
    Conserved Domains (2) summary
    sd00039
    Location:294332
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:273490
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_135153.4NP_608997.3  WD repeat domain 79, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608997.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMH1
    Conserved Domains (3) summary
    COG2319
    Location:231453
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:255293
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:234451
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...