Gal beta galactosidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Galprovided by FlyBase
Official Full Name: beta galactosidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0001089
Locus tag: Dmel_CG9092
See related: AllianceGenome:FB:FBgn0001089
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: beta-gal; beta-GAL; beta-Gal-1; CG9092; dbeta-Gal; DmelGal; Dmel\CG9092; gal; lacZ-1
Summary: Enables beta-galactosidase activity and protein homodimerization activity. Involved in galactose metabolic process. Predicted to be active in vacuole. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to several human genes including GLB1L (galactosidase beta 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 26B2-26B2; 2-18 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6003574..6006827, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6003574..6006827, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional loss of glucocerebrosidase or beta-Gal promotes toxic conversion of alphaSyn via aberrant interactions between alphaSyn and their substrate glycolipids, leading to aggravation of alphaSyn-mediated neurodegeneration.
Title: Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables beta-galactosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactosidase activity	IDA Inferred from Direct Assay more info
enables beta-galactosidase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in galactose catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactose metabolic process	IDA Inferred from Direct Assay more info
involved_in glycoprotein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in vacuole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta galactosidase

Names: CG9092-PA; CG9092-PB; Gal-PA; Gal-PB; beta-galactosidase; beta-galactosidase-1

NP_001260120.1

EC 3.2.1.-

EC 3.2.1.23

NP_608978.2

EC 3.2.1.-

EC 3.2.1.23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6003574..6006827 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273191.1 → NP_001260120.1 beta galactosidase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260120.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCA6

Conserved Domains (2) summary

pfam01301
Location:52 → 374

Glyco_hydro_35; Glycosyl hydrolases family 35

pfam13364
Location:568 → 635

BetaGal_dom4_5; Beta-galactosidase jelly roll domain
NM_135134.3 → NP_608978.2 beta galactosidase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608978.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VMJ5

Related

FBpp0078861

Conserved Domains (2) summary

pfam01301
Location:54 → 376

Glyco_hydro_35; Glycosyl hydrolases family 35

pfam13364
Location:570 → 637

BetaGal_dom4_5; Beta-galactosidase jelly roll domain