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ifc - infertile crescent

Enables sphingolipid delta-4 desaturase activity. Involved in negative regulation of lipophagy. Located in endoplasmic reticulum and late endosome. Is expressed in several structures, including Malpighian tubule primordium; circulatory system primordium; embryonic/larval midgut primordium; germline cell; and gut section. Used to study neurodegenerative disease and obesity. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 18. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1) and DEGS2 (delta 4-desaturase, sphingolipid 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa