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Ucp4B Uncoupling protein 4B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33833, updated on 9-Dec-2024

Summary

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Official Symbol
Ucp4Bprovided by FlyBase
Official Full Name
Uncoupling protein 4Bprovided by FlyBase
Primary source
FLYBASE:FBgn0031758
Locus tag
Dmel_CG18340
See related
AllianceGenome:FB:FBgn0031758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18340; Dmel\CG18340; dmUCP4b; DmUCP4B; Ucp 4b; ucp4B; Ucp4b; UCP4B
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in response to cold. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ucp4B in Genome Data Viewer
Location:
26A5-26A5; 2-18 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5969859..5971025)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5969859..5971025)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43465 Neighboring gene Uncoupling protein 4C Neighboring gene chickadee Neighboring gene eukaryotic translation initiation factor 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein. Hanák P, et al. FEBS Lett, 2001 Apr 27. PMID 11334880
  2. UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. Da-Ré C, et al. EMBO Rep, 2014 May. PMID 24639557, Free PMC Article
  3. Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family. Sokolova IM, et al. FEBS Lett, 2005 Jan 17. PMID 15642337
  4. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease. Wu K, et al. FASEB J, 2014 Dec. PMID 25145627
  5. In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury. Constantinou C, et al. Int J Mol Med, 2016 Feb. PMID 26648055, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncoupling protein 4B
Names
CG18340-PA
CG18340-PB
CG18340-PC
Ucp4B-PA
Ucp4B-PB
Ucp4B-PC
uncoupling protein 4b

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5969859..5971025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135133.3 → NP_608977.1  uncoupling protein 4B, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608977.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VMK0
    Related
    FBpp0078804
    Conserved Domains (2) summary
    PTZ00169
    Location:32 → 306
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:246 → 331
    Mito_carr; Mitochondrial carrier protein

  2. NM_001258975.2 → NP_001245904.1  uncoupling protein 4B, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245904.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NDG1
    Conserved Domains (1) summary
    pfam00153
    Location:138 → 225
    Mito_carr; Mitochondrial carrier protein

  3. NM_164666.3 → NP_723135.1  uncoupling protein 4B, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723135.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPK1
    Related
    FBpp0078805
    Conserved Domains (1) summary
    pfam00153
    Location:32 → 129
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDG1 M9NDG1
Q8IPK1 Q8IPK1
Q9VMK0 Q9VMK0

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