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Ucp4C Uncoupling protein 4C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33832, updated on 9-Dec-2024

Summary

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Official Symbol
Ucp4Cprovided by FlyBase
Official Full Name
Uncoupling protein 4Cprovided by FlyBase
Primary source
FLYBASE:FBgn0031757
Locus tag
Dmel_CG9064
See related
AllianceGenome:FB:FBgn0031757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO02079478.1; anon-WO02079478.2; anon-WO0242455.3; anon-WO0242455.4; anon-WO03037362.7; anon-WO03061681.1; anon-WO03061681.2; CG9064; Dmel\CG9064; dmUCP4c; DmUCP4C; dUCP4c; ucp4c; ucp4C; Ucp4c; UCP4c; UCP4C
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in response to cold. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ucp4C in Genome Data Viewer
Location:
26A4-26A5; 2-18 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5968566..5969761)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5968566..5969761)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene palisade Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43465 Neighboring gene Uncoupling protein 4B Neighboring gene chickadee

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. Da-Ré C, et al. EMBO Rep, 2014 May. PMID 24639557, Free PMC Article
  2. Mitochondrial uncoupling proteins and phylogenesis--UCP4 as the ancestral uncoupling protein. Hanák P, et al. FEBS Lett, 2001 Apr 27. PMID 11334880
  3. Evolution of mitochondrial uncoupling proteins: novel invertebrate UCP homologues suggest early evolutionary divergence of the UCP family. Sokolova IM, et al. FEBS Lett, 2005 Jan 17. PMID 15642337
  4. Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans. De Luca M, et al. BMC Genet, 2008 Aug 11. PMID 18694491, Free PMC Article
  5. UCP4A protects against mitochondrial dysfunction and degeneration in pink1/parkin models of Parkinson's disease. Wu K, et al. FASEB J, 2014 Dec. PMID 25145627

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncoupling protein 4C
Names
CG9064-PA
Ucp4C-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5968566..5969761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135132.3 → NP_608976.1  uncoupling protein 4C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608976.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VMK1
    Related
    FBpp0078803
    Conserved Domains (1) summary
    pfam00153
    Location:237 → 329
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VMK1.1 Q9VMK1

Gene LinkOut

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